Novel poly(ε-caprolactone)/graphene scaffolds for bone cancer treatment and bone regeneration

Hou, Yanhao, Wang, Weiguang and Da Silva Bartolo, Paulo Jorge (2020) Novel poly(ε-caprolactone)/graphene scaffolds for bone cancer treatment and bone regeneration. 3D Printing and Additive Manufacturing, 7 (5), 222-229. (doi:10.1089/3dp.2020.0051).

Record type: Article

Abstract

Scaffold-based bone tissue engineering is the most relevant approaches for critical-size bone defects. It is based on the use of three-dimensional substrates to provide the appropriate biomechanical environment for bone regeneration. Despite some successful results previously reported, scaffolds were never designed for diseases treatment applications. This paper proposes a novel dual-functional scaffold for cancer applications, comprising both treatment and regeneration functions. These functions are achieved by combining a biocompatible and biodegradable polymer and graphene. Results indicate that high concentrations of graphene enhance the mechanical properties of the scaffolds, increasing also the inhibition on cancer cell viability and proliferation.

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e-pub ahead of print date: 12 August 2020

Published date: 15 October 2020

Additional Information: Funding Information: Authors declare the funding received from Rosetrees Trust and Stoneygate (Rosetrees & Stoneygate Trust Young Enterprise Fellowship, grant number: A2750/ M874), and Engineering and Physical Sciences Research Council (EPSRC) of the UK (Global Challenges Research Fund, grant number: EP/R01513/1). Publisher Copyright: © Yanhao Hou et al., 2020; Published by Mary Ann Liebert, Inc. 2020. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.