READ ME File For 'Novel strategies in the early detection of pancreatic ductal adenocarcinoma'

Dataset DOI: 10.5258/SOTON/D3211

ReadMe Author: DECLAN MCDONNELL, University of Southampton ORCID ID: 0000-0001-9088-9875

This dataset supports the thesis entitled 
AWARDED BY: Univeristy of Southampton
DATE OF AWARD: September 2024

DESCRIPTION OF THE DATA

This dataset contains:
Files accessible using Stata 16 or higher (.dta). .xlsx files are opened with Microsoft Excel. .mat files require MatLab R2018a or higher to open.
Chapter 2 was sourced directly from the UK Biobank and trimmed down to leave the necessary information required to conduct the analyses - this is file UKBB_1157, which reflects the number of incident PDAC cases without diabetes. Contact UK Biobank to access the original data
Chapter 3 uses the data contained the Excel spread sheet (DEPEND_study_data_collection_final.xlsx) and Final_DEPEND_data.dta containing all of the information and breath testing and NMR results for the DEPEND participants. 
Chapter 4 uses the files HVPDAC_final.dta and Final_DEPEND_data.dta files which contains all of the metabolomics results. These were also sourced from rawdata.mat which contains the raw NMR data


Date of data collection: UK Biobank data collected from 2006 to 25th September 2020. Downloaded August 2021. DEPEND data collected from participants March 2021 to March 2022.

Information about geographic location of data collection: 

Licence:
Creative Commons Attribution CC-BY 

Related projects/Funders:
Cancer Research UK: C45617/A29908

Related publication:
McDonnell D, Afolabi PR, Wilding S, Griffiths GO, Swann JR, Byrne CD, Hamady ZZ. Utilising Pancreatic Exocrine Insufficiency in the Detection of Resectable Pancreatic Ductal Adenocarcinoma. Cancers (Basel). 2023 Dec 8;15(24):5756. doi: 10.3390/cancers15245756. PMID: 38136302; PMCID: PMC10741412.
McDonnell D, Cheang AWE, Wilding S, Wild SH, Frampton AE, Byrne CD, Hamady ZZ. Elevated Glycated Haemoglobin (HbA1c) Is Associated with an Increased Risk of Pancreatic Ductal Adenocarcinoma: A UK Biobank Cohort Study. Cancers (Basel). 2023 Aug 13;15(16):4078. doi: 10.3390/cancers15164078. PMID: 37627106; PMCID: PMC10452109.
Afolabi PR, McDonnell D, Byrne CD, Wilding S, Goss V, Walters J, Hamady ZZ. DEPEND study protocol: early detection of patients with pancreatic cancer - a pilot study to evaluate the utility of faecal elastase-1 and 13C-mixed triglyceride breath test as screening tools in high-risk individuals. BMJ Open. 2022 Feb 25;12(2):e057271. doi: 10.1136/bmjopen-2021-057271. PMID: 35217541; PMCID: PMC8883257.
Date that the file was created: Aug, 2023