A narrative review of the evidence supporting nutritional supplementation for better muscle health in older adults
A narrative review of the evidence supporting nutritional supplementation for better muscle health in older adults
Sarcopenia is characterised by progressive and generalised decline in muscle strength, function, and muscle mass. Now recognised as a muscle disease, it is highly prevalent in older adults, with estimates of up to 30% in some populations. Sarcopenia has a complex multifactorial aetiology, including cellular and molecular changes, chronic disease, lower physical activity as well as nutritional deficiency. Sarcopenia is associated with a range of adverse physical and metabolic outcomes leading to disability, morbidity, impaired quality of life and mortality. Given the demographic shifts in the population, there is an urgent need to improve skeletal muscle health in older adults. Unfortunately, there are no pharmacologic therapies suitable for widespread use currently. In this short review, we discuss the existing literature reporting the benefits of various options for nutritional supplementation in older sarcopenic participants or healthy older adults. Several systematic reviews have been
Patel, Harnish P.
e1c0826f-d14e-49f3-8049-5b945d185523
Laskou, Faidra
ea7e7a54-092d-4baf-8b18-e0d62c47b878
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
23 January 2025
Patel, Harnish P.
e1c0826f-d14e-49f3-8049-5b945d185523
Laskou, Faidra
ea7e7a54-092d-4baf-8b18-e0d62c47b878
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Patel, Harnish P., Laskou, Faidra and Dennison, Elaine M.
(2025)
A narrative review of the evidence supporting nutritional supplementation for better muscle health in older adults.
OBM Geriatrics, 9 (1), [296].
(doi:10.21926/obm.geriatr.2501296).
Abstract
Sarcopenia is characterised by progressive and generalised decline in muscle strength, function, and muscle mass. Now recognised as a muscle disease, it is highly prevalent in older adults, with estimates of up to 30% in some populations. Sarcopenia has a complex multifactorial aetiology, including cellular and molecular changes, chronic disease, lower physical activity as well as nutritional deficiency. Sarcopenia is associated with a range of adverse physical and metabolic outcomes leading to disability, morbidity, impaired quality of life and mortality. Given the demographic shifts in the population, there is an urgent need to improve skeletal muscle health in older adults. Unfortunately, there are no pharmacologic therapies suitable for widespread use currently. In this short review, we discuss the existing literature reporting the benefits of various options for nutritional supplementation in older sarcopenic participants or healthy older adults. Several systematic reviews have been
Text
obm.geriatr.2501296 (1)
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Accepted/In Press date: 16 January 2025
Published date: 23 January 2025
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For the purpose of Open Access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission.
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Local EPrints ID: 498280
URI: http://eprints.soton.ac.uk/id/eprint/498280
PURE UUID: 3f7a1de4-7290-49e0-85d2-9d47a6e79ba1
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Date deposited: 13 Feb 2025 17:51
Last modified: 17 Oct 2025 02:14
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Author:
Harnish P. Patel
Author:
Faidra Laskou
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