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Social jetlag and cardiometabolic risk in preadolescent children

Social jetlag and cardiometabolic risk in preadolescent children
Social jetlag and cardiometabolic risk in preadolescent children

Objective: childhood cardiometabolic disease risk (CMD) has been associated with short sleep duration. Its relationship with other aspects of sleep should also be considered, including social jetlag (SJL) which represents the difference between a person's social rhythms and circadian clock. This study investigated whether childhood CMD risk is associated with sleep duration, sleep disturbances, and SJL. 

Study design: the observational study included 332 children aged 8-10 years (48.5% female). The three independent variables were sleep duration, sleep disturbances, and SJL. SJL was calculated as the variation in hours between the midpoint of sleep during free (weekend) days and work/school days. Eleven cardiometabolic biomarkers were measured, including central blood pressure, lipids, glycated hemoglobin, arterial wave reflection, and glucose. Underlying CMD risk factors were identified using factor analysis.

Results: four underlying CMD risk factors were identified using factor analysis: blood pressure, cholesterol, vascular health, and carbohydrate metabolism. Neither sleep disturbances nor sleep duration were significantly associated with any of the four CMD factors following adjustments to potential confounders. However, SJL was significantly linked to vascular health (p = 0.027) and cholesterol (p = 0.025). 

Conclusion: these findings suggest that SJL may be a significant and measurable public health target for offsetting negative CMD trajectories in children. Further studies are required to determine biological plausibility.

2297-055X
Castro, Nicholas
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Diana, Jake
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Blackwell, Jade
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Faulkner, James
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Lark, Sally
4efafc16-2d48-4e22-8337-b6fb410f70a6
Skidmore, Paula
d538e7da-b185-4c7f-9ef3-fa130293bb63
Hamlin, Michael
0c52e9a4-6d8a-4237-b502-4853ce9cdfe3
Signal, Leigh
c4a53daf-8aef-4d56-ab62-5e26ad2d33ef
Williams, Michelle A.
90364b54-80d0-4070-ace1-349149da998e
Stoner, Lee
fc664371-fcdc-412d-b2c2-1c1ce983b95e
Castro, Nicholas
dfd91206-043a-4856-a79f-328eaaeb765b
Diana, Jake
296a3c22-f284-4e78-a7fe-7f668bec1dbb
Blackwell, Jade
0687dd29-e5be-4732-a1a9-e70d21cc5c2b
Faulkner, James
b2bd38c9-667c-42e8-ad1e-6df58d1e3f7a
Lark, Sally
4efafc16-2d48-4e22-8337-b6fb410f70a6
Skidmore, Paula
d538e7da-b185-4c7f-9ef3-fa130293bb63
Hamlin, Michael
0c52e9a4-6d8a-4237-b502-4853ce9cdfe3
Signal, Leigh
c4a53daf-8aef-4d56-ab62-5e26ad2d33ef
Williams, Michelle A.
90364b54-80d0-4070-ace1-349149da998e
Stoner, Lee
fc664371-fcdc-412d-b2c2-1c1ce983b95e

Castro, Nicholas, Diana, Jake, Blackwell, Jade, Faulkner, James, Lark, Sally, Skidmore, Paula, Hamlin, Michael, Signal, Leigh, Williams, Michelle A. and Stoner, Lee (2021) Social jetlag and cardiometabolic risk in preadolescent children. Frontiers in Cardiovascular Medicine, 8, [705169]. (doi:10.3389/fcvm.2021.705169).

Record type: Article

Abstract

Objective: childhood cardiometabolic disease risk (CMD) has been associated with short sleep duration. Its relationship with other aspects of sleep should also be considered, including social jetlag (SJL) which represents the difference between a person's social rhythms and circadian clock. This study investigated whether childhood CMD risk is associated with sleep duration, sleep disturbances, and SJL. 

Study design: the observational study included 332 children aged 8-10 years (48.5% female). The three independent variables were sleep duration, sleep disturbances, and SJL. SJL was calculated as the variation in hours between the midpoint of sleep during free (weekend) days and work/school days. Eleven cardiometabolic biomarkers were measured, including central blood pressure, lipids, glycated hemoglobin, arterial wave reflection, and glucose. Underlying CMD risk factors were identified using factor analysis.

Results: four underlying CMD risk factors were identified using factor analysis: blood pressure, cholesterol, vascular health, and carbohydrate metabolism. Neither sleep disturbances nor sleep duration were significantly associated with any of the four CMD factors following adjustments to potential confounders. However, SJL was significantly linked to vascular health (p = 0.027) and cholesterol (p = 0.025). 

Conclusion: these findings suggest that SJL may be a significant and measurable public health target for offsetting negative CMD trajectories in children. Further studies are required to determine biological plausibility.

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Accepted/In Press date: 10 September 2021
Published date: 7 October 2021

Identifiers

Local EPrints ID: 498310
URI: http://eprints.soton.ac.uk/id/eprint/498310
ISSN: 2297-055X
PURE UUID: ee4baabf-5147-4afc-936d-a2f7b4be2826
ORCID for James Faulkner: ORCID iD orcid.org/0000-0002-3704-6737

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Date deposited: 14 Feb 2025 17:37
Last modified: 22 Aug 2025 02:46

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Contributors

Author: Nicholas Castro
Author: Jake Diana
Author: Jade Blackwell
Author: James Faulkner ORCID iD
Author: Sally Lark
Author: Paula Skidmore
Author: Michael Hamlin
Author: Leigh Signal
Author: Michelle A. Williams
Author: Lee Stoner

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