Roles of prostaglandins and cyclooxygenases in autism spectrum disorder: a comprehensive review
Roles of prostaglandins and cyclooxygenases in autism spectrum disorder: a comprehensive review
Purpose of review: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with multifaceted etiologies. Emerging evidence implicates dysregulation of prostaglandins and cyclooxygenase (COX) enzymes in ASD pathophysiology. This review aims to explore key mechanisms through which prostaglandins and COX enzymes may influence ASD.
Recent findings: recent research highlights significant roles for prostaglandins and COX enzymes in modulating Wnt (Wingless and Int-1) signalling pathways, which are known autism susceptibility pathways, as well as in regulating dendritic arborisation and cerebellar function. Polymorphisms in COX genes have also been linked to ASD, indicating a genetic component to this dysregulation. Furthermore, prostaglandins and COX enzymes show potential as biomarkers for ASD.
Summary: the accumulated evidence underscores the involvement of prostaglandins and COX enzymes in ASD pathophysiology. This insight offers a deeper understanding of the disorder and may pave the way for more effective diagnostic and treatment strategies.
autism, prostaglanding, Prostaglandins, Autism spectrum disorder (ASD), Cyclooxygenases (COX), Wnt pathway, COX polymorphisms, Neurodevelopment, Neuroinflammation
Kamal, Datu Agasi Mohd
5dc774eb-f96b-4b7d-ba05-ad545009c450
Abidin, Shahidee Zainal
c3636dac-da29-4515-a1cf-33cb87b4fe32
Saudi, Wan Salman Wan
6fed5e1b-0da8-4cce-bc6e-2ac7a27b39c8
Kumar, Jaya
543e32da-b7b9-4f3f-9b1e-7ea6315e826d
Bellato, Alessio
0ee4c34f-3850-4883-8b82-5717b74990f7
23 January 2025
Kamal, Datu Agasi Mohd
5dc774eb-f96b-4b7d-ba05-ad545009c450
Abidin, Shahidee Zainal
c3636dac-da29-4515-a1cf-33cb87b4fe32
Saudi, Wan Salman Wan
6fed5e1b-0da8-4cce-bc6e-2ac7a27b39c8
Kumar, Jaya
543e32da-b7b9-4f3f-9b1e-7ea6315e826d
Bellato, Alessio
0ee4c34f-3850-4883-8b82-5717b74990f7
Kamal, Datu Agasi Mohd, Abidin, Shahidee Zainal, Saudi, Wan Salman Wan, Kumar, Jaya and Bellato, Alessio
(2025)
Roles of prostaglandins and cyclooxygenases in autism spectrum disorder: a comprehensive review.
Current Behavioral Neuroscience Reports, 12 (1), [2].
(doi:10.1007/s40473-024-00294-7).
Abstract
Purpose of review: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with multifaceted etiologies. Emerging evidence implicates dysregulation of prostaglandins and cyclooxygenase (COX) enzymes in ASD pathophysiology. This review aims to explore key mechanisms through which prostaglandins and COX enzymes may influence ASD.
Recent findings: recent research highlights significant roles for prostaglandins and COX enzymes in modulating Wnt (Wingless and Int-1) signalling pathways, which are known autism susceptibility pathways, as well as in regulating dendritic arborisation and cerebellar function. Polymorphisms in COX genes have also been linked to ASD, indicating a genetic component to this dysregulation. Furthermore, prostaglandins and COX enzymes show potential as biomarkers for ASD.
Summary: the accumulated evidence underscores the involvement of prostaglandins and COX enzymes in ASD pathophysiology. This insight offers a deeper understanding of the disorder and may pave the way for more effective diagnostic and treatment strategies.
Text
s40473-024-00294-7
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More information
Accepted/In Press date: 28 December 2024
Published date: 23 January 2025
Keywords:
autism, prostaglanding, Prostaglandins, Autism spectrum disorder (ASD), Cyclooxygenases (COX), Wnt pathway, COX polymorphisms, Neurodevelopment, Neuroinflammation
Identifiers
Local EPrints ID: 498368
URI: http://eprints.soton.ac.uk/id/eprint/498368
ISSN: 2196-2979
PURE UUID: c9a264ca-1f28-43c9-b5fd-6a06d2fd6440
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Date deposited: 17 Feb 2025 17:45
Last modified: 22 Aug 2025 02:41
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Contributors
Author:
Datu Agasi Mohd Kamal
Author:
Shahidee Zainal Abidin
Author:
Wan Salman Wan Saudi
Author:
Jaya Kumar
Author:
Alessio Bellato
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