Critical re-evaluation of FABMS analysis of ligand-cation interactions
Critical re-evaluation of FABMS analysis of ligand-cation interactions
Whilst the use of FABMS in the analysis of ligand-cation interactions has become widespread, there are a number of experimental variables associated with the use of this technique, the effects of which have not previously been addressed. The interactions of 12-crown-4, 15-crown-5 and 18-crown-6 with the alkali metal cations reveal two important observations: (i) that the matrix employed for the FAB studies has a dramatic effect on the observed binding behaviour and (ii) that the observed relative intensities of protonated ions ([M + H]+) and metallated ions ([M + Metal]+) differ enormously. Determination of the ratios of these signals would allow quantitative arguments to be applied to experiments of this type. Accordingly, previous reports of the use of FABMS for the quantitative study of ligand-cation interactions must be viewed with caution.
929-933
Langley, G. John
7ac80d61-b91d-4261-ad17-255f94ea21ea
Hamilton, Darren G.
71e5fdd1-3b27-439a-b7bb-38a7af4fa5d9
Grossel, Martin C.
403bf3ff-6364-44e9-ab46-52d84c6f0d56
1995
Langley, G. John
7ac80d61-b91d-4261-ad17-255f94ea21ea
Hamilton, Darren G.
71e5fdd1-3b27-439a-b7bb-38a7af4fa5d9
Grossel, Martin C.
403bf3ff-6364-44e9-ab46-52d84c6f0d56
Langley, G. John, Hamilton, Darren G. and Grossel, Martin C.
(1995)
Critical re-evaluation of FABMS analysis of ligand-cation interactions.
Journal of the Chemical Society, Perkin Transactions 2, (5), .
(doi:10.1039/p29950000929).
Abstract
Whilst the use of FABMS in the analysis of ligand-cation interactions has become widespread, there are a number of experimental variables associated with the use of this technique, the effects of which have not previously been addressed. The interactions of 12-crown-4, 15-crown-5 and 18-crown-6 with the alkali metal cations reveal two important observations: (i) that the matrix employed for the FAB studies has a dramatic effect on the observed binding behaviour and (ii) that the observed relative intensities of protonated ions ([M + H]+) and metallated ions ([M + Metal]+) differ enormously. Determination of the ratios of these signals would allow quantitative arguments to be applied to experiments of this type. Accordingly, previous reports of the use of FABMS for the quantitative study of ligand-cation interactions must be viewed with caution.
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Published date: 1995
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Local EPrints ID: 499039
URI: http://eprints.soton.ac.uk/id/eprint/499039
ISSN: 1472-779X
PURE UUID: 0e4208d8-db07-4699-9186-0433fbfaa1d5
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Last modified: 08 Mar 2025 02:34
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Author:
Darren G. Hamilton
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