Synthesis of an unnatural product -- 4,4′ biaryl formation as a macrocyclisation step

Patel, Hitesh K., Kilburn, Jeremy D., Langley, G. John, Edwards, Peter D., Mitchell, Tim and Southgate, Robert (1994) Synthesis of an unnatural product -- 4,4′ biaryl formation as a macrocyclisation step. Tetrahedron Letters, 35 (3), 481-484. (doi:10.1016/0040-4039(94)85086-0).

Record type: Article

Abstract

A novel macrocycle featuring a crown ether ring, amide functionality and a rigid biaryl unit has been prepared as a potential receptor for small peptidic guests. The synthesis of the macrocycle includes a palladium catalysed biaryl formation as the ring-closing step.

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Published date: 17 January 1994

Additional Information: Note: the following correction was published in Tetrahedron Letters, 35(8), 1114. https://doi.org/10.1016/0040-4039(94)88001-8 In the discussion of the mass spectrometry results in the dinal paragraph of the paper, the reference tp peaks inthe negative ion FAB MS, corresponding to macrocycle 1, M-,and to (macrocycIe + carboxylate anion + K+), should refer to macrocycIe 1, (M - H)-, and to (macrocycIe + carbxylate anion + potassium - H)- respectively.

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