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International Consortium to Classify Ageing-Related Pathologies (ICCARP) senescence definitions: achieving international consensus

International Consortium to Classify Ageing-Related Pathologies (ICCARP) senescence definitions: achieving international consensus
International Consortium to Classify Ageing-Related Pathologies (ICCARP) senescence definitions: achieving international consensus
With the global increase in ageing populations, a clear understanding of the physiological and pathological changes associated with ageing is vital for advancing research and clinical practice. Following the World Health Organization’s decision to classify age-related aetiologies, the International Consortium to Classify Ageing-Related Pathologies (ICCARP) was established in 2023, led by Cardiff Metropolitan University.
The aim of the ICCARP is to develop a systematic and comprehensive classification system for ageing-related changes including pathologies, diseases, and syndromes. Currently, the ICCARP is in the process of identifying all phenomena that meet the criteria for ageing-related pathologies, to develop proposals for grouping and naming them within a comprehensive classification system. However, during the course of this project, it became evident that certain terms, specifically relating to ‘senescence’, were interpreted and understood in multiple ways, often dependent upon the professional background of an expert and the context in which the term was being used. To achieve our goals, it is vital that we use a universal language when naming and proposing ageing-related changes to provide a clear, unambiguous understanding of the changes and their underlying contribution to maintaining or degrading organismal integrity (physiology versus pathology). Furthermore, establishing clear nomenclature will be advantageous in the wider efforts to unify the study of ageing, and to better align research and clinical practice.
The purpose of this letter is to explicitly state the definitions primarily relating to ‘senescence’ that will be used by the ICCARP, as agreed by ICCARP members through consensus meetings in 2024. The terms that will be defined are:
1. Normative ageing 2. Senescence3. Cellular senescence, including acute and chronic senescence4. Physiological senescence5. Pathological senescence6. Tissue senescence7. Organ senescence8. Systems senescence9. Organismal senescence
2509-2715
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Tsimpida, Dialechti
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Venables, Zoe C.
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Wellington, Jack
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Calimport, Stuart R.G.
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Bentley, Barry L.
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Short, Emma, Huckstepp, Robert T.R., Alavian, Kambiz, Amoaku, Winfried M.K., Barber, Thomas M., van Beek, Edwin J.R., Benbow, Emyr, Bhandari, Sunil, Bloom, Phillip, Cota, Carlo, Chazot, Paul, Christopher, Gary, Demaria, Marco, Erusalimsky, Jorge D., Ferenbach, David A., Foster, Thomas, Gazzard, Gus, Glassock, Richard, Jamal, Noordin, Kalaria, Raj, Kanamarlapudi, Venkateswarlu, Khan, Adnan H., Krishna, Yamini, Leeuwenburgh, Christiaan, van der Linde, Ian, Lorenzini, Antonello, Maier, Andrea Britta, Medina, Reinhold J., Miotto, Cecilia L., Mukherjee, Abhik, Mukkanna, Krishna, Murray, James T., Nirenberg, Alexander, Palmer, Donald B., Pawelec, Graham, Reddy, Venkat, Rosa, Arianna Caroline, Rule, Andrew D., Shiels, Paul G., Sheridan, Carl, Tree, Jeremy, Tsimpida, Dialechti, Venables, Zoe C., Wellington, Jack, Calimport, Stuart R.G. and Bentley, Barry L. (2025) International Consortium to Classify Ageing-Related Pathologies (ICCARP) senescence definitions: achieving international consensus. GeroScience. (doi:10.6084/M9.FIGSHARE.27969546).

Record type: Article

Abstract

With the global increase in ageing populations, a clear understanding of the physiological and pathological changes associated with ageing is vital for advancing research and clinical practice. Following the World Health Organization’s decision to classify age-related aetiologies, the International Consortium to Classify Ageing-Related Pathologies (ICCARP) was established in 2023, led by Cardiff Metropolitan University.
The aim of the ICCARP is to develop a systematic and comprehensive classification system for ageing-related changes including pathologies, diseases, and syndromes. Currently, the ICCARP is in the process of identifying all phenomena that meet the criteria for ageing-related pathologies, to develop proposals for grouping and naming them within a comprehensive classification system. However, during the course of this project, it became evident that certain terms, specifically relating to ‘senescence’, were interpreted and understood in multiple ways, often dependent upon the professional background of an expert and the context in which the term was being used. To achieve our goals, it is vital that we use a universal language when naming and proposing ageing-related changes to provide a clear, unambiguous understanding of the changes and their underlying contribution to maintaining or degrading organismal integrity (physiology versus pathology). Furthermore, establishing clear nomenclature will be advantageous in the wider efforts to unify the study of ageing, and to better align research and clinical practice.
The purpose of this letter is to explicitly state the definitions primarily relating to ‘senescence’ that will be used by the ICCARP, as agreed by ICCARP members through consensus meetings in 2024. The terms that will be defined are:
1. Normative ageing 2. Senescence3. Cellular senescence, including acute and chronic senescence4. Physiological senescence5. Pathological senescence6. Tissue senescence7. Organ senescence8. Systems senescence9. Organismal senescence

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More information

Accepted/In Press date: 31 December 2024
e-pub ahead of print date: 21 February 2025

Identifiers

Local EPrints ID: 499133
URI: http://eprints.soton.ac.uk/id/eprint/499133
DOI: doi:10.6084/M9.FIGSHARE.27969546
ISSN: 2509-2715
PURE UUID: d3cb6948-67e1-4823-8911-ff988083ab7b
ORCID for Adnan H. Khan: ORCID iD orcid.org/0000-0001-8153-8002
ORCID for Dialechti Tsimpida: ORCID iD orcid.org/0000-0002-3709-5651

Catalogue record

Date deposited: 10 Mar 2025 17:57
Last modified: 22 Aug 2025 02:41

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Contributors

Author: Emma Short
Author: Robert T.R. Huckstepp
Author: Kambiz Alavian
Author: Winfried M.K. Amoaku
Author: Thomas M. Barber
Author: Edwin J.R. van Beek
Author: Emyr Benbow
Author: Sunil Bhandari
Author: Phillip Bloom
Author: Carlo Cota
Author: Paul Chazot
Author: Gary Christopher
Author: Marco Demaria
Author: Jorge D. Erusalimsky
Author: David A. Ferenbach
Author: Thomas Foster
Author: Gus Gazzard
Author: Richard Glassock
Author: Noordin Jamal
Author: Raj Kalaria
Author: Venkateswarlu Kanamarlapudi
Author: Adnan H. Khan ORCID iD
Author: Yamini Krishna
Author: Christiaan Leeuwenburgh
Author: Ian van der Linde
Author: Antonello Lorenzini
Author: Andrea Britta Maier
Author: Reinhold J. Medina
Author: Cecilia L. Miotto
Author: Abhik Mukherjee
Author: Krishna Mukkanna
Author: James T. Murray
Author: Alexander Nirenberg
Author: Donald B. Palmer
Author: Graham Pawelec
Author: Venkat Reddy
Author: Arianna Caroline Rosa
Author: Andrew D. Rule
Author: Paul G. Shiels
Author: Carl Sheridan
Author: Jeremy Tree
Author: Dialechti Tsimpida ORCID iD
Author: Zoe C. Venables
Author: Jack Wellington
Author: Stuart R.G. Calimport
Author: Barry L. Bentley

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