Exploitation of feedback in enzyme‐catalysed reactions
Exploitation of feedback in enzyme‐catalysed reactions
Some cellular systems, such as yeast, bacteria and slime mould, display dynamic behavior including switches and rhythms driven by feedback in enzyme-catalysed reactions. The mechanisms of these processes have been well investigated and recent attention has turned to generating similar responses in synthetic biocatalytic systems, with a view to creating bioinspired analogues for applications. Here we discuss how feedback arises in the reaction mechanisms of some enzyme-catalyzed reactions in vitro, the behaviour obtained and the emerging applications. These autocatalytic reactions may provide insights into behaviour in cellular systems as well as new methods for drug delivery, sensing and repair that can be exploited in living systems.
706-713
Támás Bánsági, Jr
21bc8b8e-9552-407c-a74a-59c0d34f2b7f
Taylor, Annette F.
08028a29-428d-4732-b6b1-f7a93389b386
Támás Bánsági, Jr
21bc8b8e-9552-407c-a74a-59c0d34f2b7f
Taylor, Annette F.
08028a29-428d-4732-b6b1-f7a93389b386
Támás Bánsági, Jr and Taylor, Annette F.
(2018)
Exploitation of feedback in enzyme‐catalysed reactions.
Israel Journal of Chemistry, 58 (6-7), .
(doi:10.1002/ijch.201700141).
Abstract
Some cellular systems, such as yeast, bacteria and slime mould, display dynamic behavior including switches and rhythms driven by feedback in enzyme-catalysed reactions. The mechanisms of these processes have been well investigated and recent attention has turned to generating similar responses in synthetic biocatalytic systems, with a view to creating bioinspired analogues for applications. Here we discuss how feedback arises in the reaction mechanisms of some enzyme-catalyzed reactions in vitro, the behaviour obtained and the emerging applications. These autocatalytic reactions may provide insights into behaviour in cellular systems as well as new methods for drug delivery, sensing and repair that can be exploited in living systems.
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Accepted/In Press date: 6 March 2018
e-pub ahead of print date: 29 March 2018
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Local EPrints ID: 499294
URI: http://eprints.soton.ac.uk/id/eprint/499294
ISSN: 0021-2148
PURE UUID: 45394a56-90aa-4838-b13a-47ed4be36ac9
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Date deposited: 14 Mar 2025 17:33
Last modified: 15 Mar 2025 03:14
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Author:
Jr Támás Bánsági
Author:
Annette F. Taylor
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