Risk assessment in pT1 colorectal cancer
Risk assessment in pT1 colorectal cancer
Colorectal cancer (CRC) is a common malignancy worldwide and tumour stage is closely related to clinical outcome. A small but significant proportion of submucosal-invasive (ie, pT1) CRC are associated with regional lymph node metastases (LNM) and a worse prognosis. The likelihood of LNM in pT1 CRC needs to be balanced against the operative risk and costs of surgical resection when determining the best patient management. A wide range of histopathological and clinical factors may affect LNM risk in this setting. This script provides a comprehensive overview of the tumour and patient-associated features that have been linked to LNM risk in pT1 CRC. Some of the features are well established within the literature and are included in published guidelines, while others are novel and emerging in nature. Odds ratios for LNM that are associated with key predictive features are provided where appropriate, and published models developed as an aid to the calculation of LNM risk are discussed.
225-232
Norton, Emma Jane
76746af3-fcfc-40cb-aa84-c8da09c830db
Bateman, Adrian C.
e302a81f-ca4c-48ae-9145-bff4e1ebef87
20 November 2024
Norton, Emma Jane
76746af3-fcfc-40cb-aa84-c8da09c830db
Bateman, Adrian C.
e302a81f-ca4c-48ae-9145-bff4e1ebef87
Norton, Emma Jane and Bateman, Adrian C.
(2024)
Risk assessment in pT1 colorectal cancer.
Journal of Clinical Pathology, 77 (4), .
(doi:10.1136/jcp-2023-208803).
Abstract
Colorectal cancer (CRC) is a common malignancy worldwide and tumour stage is closely related to clinical outcome. A small but significant proportion of submucosal-invasive (ie, pT1) CRC are associated with regional lymph node metastases (LNM) and a worse prognosis. The likelihood of LNM in pT1 CRC needs to be balanced against the operative risk and costs of surgical resection when determining the best patient management. A wide range of histopathological and clinical factors may affect LNM risk in this setting. This script provides a comprehensive overview of the tumour and patient-associated features that have been linked to LNM risk in pT1 CRC. Some of the features are well established within the literature and are included in published guidelines, while others are novel and emerging in nature. Odds ratios for LNM that are associated with key predictive features are provided where appropriate, and published models developed as an aid to the calculation of LNM risk are discussed.
Text
Norton - Journal of Clinical Pathology - Risk assessment in pT1 colorectal cancer
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Accepted/In Press date: 10 November 2023
e-pub ahead of print date: 10 November 2023
Published date: 20 November 2024
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Local EPrints ID: 499372
URI: http://eprints.soton.ac.uk/id/eprint/499372
ISSN: 0021-9746
PURE UUID: ccc584f4-66ce-49db-b3b6-576ee0c81f37
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Date deposited: 18 Mar 2025 17:37
Last modified: 22 Aug 2025 02:44
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Author:
Emma Jane Norton
Author:
Adrian C. Bateman
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