Critical variables regulating age-related anabolic responses to protein nutrition in skeletal muscle
Critical variables regulating age-related anabolic responses to protein nutrition in skeletal muscle
Protein nutrition is critical for the maintenance of skeletal muscle mass across the lifecourse and for the growth of muscle in response to resistance exercise - both acting via the stimulation of protein synthesis. The transient anabolic response to protein feeding may vary in magnitude and duration, depending on, e.g., timing, dose, amino acid composition and delivery mode, which are in turn influenced by physical activity and age. This review aims to: (i) summarise the fundamental metabolic responses of muscle to protein feeding, (ii) discuss key variables regulating muscle anabolic responses to protein feeding, and (iii) explore how these variables can be optimised for muscle anabolism in response to physical activity and ageing.
Deane, Colleen S.
3320532e-f411-4ea8-9a14-4a9f248da898
Cox, Jake
fa07d726-f0ae-405e-8ff5-84210de8b7cd
Atherton, Philip J.
b9c1604a-deaa-4174-8b72-e564dd72dd68
6 August 2024
Deane, Colleen S.
3320532e-f411-4ea8-9a14-4a9f248da898
Cox, Jake
fa07d726-f0ae-405e-8ff5-84210de8b7cd
Atherton, Philip J.
b9c1604a-deaa-4174-8b72-e564dd72dd68
Deane, Colleen S., Cox, Jake and Atherton, Philip J.
(2024)
Critical variables regulating age-related anabolic responses to protein nutrition in skeletal muscle.
Frontiers in Nutrition, 11.
(doi:10.3389/fnut.2024.1419229).
Abstract
Protein nutrition is critical for the maintenance of skeletal muscle mass across the lifecourse and for the growth of muscle in response to resistance exercise - both acting via the stimulation of protein synthesis. The transient anabolic response to protein feeding may vary in magnitude and duration, depending on, e.g., timing, dose, amino acid composition and delivery mode, which are in turn influenced by physical activity and age. This review aims to: (i) summarise the fundamental metabolic responses of muscle to protein feeding, (ii) discuss key variables regulating muscle anabolic responses to protein feeding, and (iii) explore how these variables can be optimised for muscle anabolism in response to physical activity and ageing.
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fnut-11-1419229
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Accepted/In Press date: 23 July 2024
Published date: 6 August 2024
Identifiers
Local EPrints ID: 499429
URI: http://eprints.soton.ac.uk/id/eprint/499429
ISSN: 2296-861X
PURE UUID: 7f27b62d-052c-4531-a06f-142126a9d820
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Date deposited: 19 Mar 2025 17:47
Last modified: 22 Aug 2025 02:36
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Author:
Colleen S. Deane
Author:
Jake Cox
Author:
Philip J. Atherton
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