Base-catalyzed feedback in the urea-urease reaction
Base-catalyzed feedback in the urea-urease reaction
The bell-shaped rate−pH curve coupled to production of base in the urea−urease reaction was utilized to give feedback-driven behavior: an acid-to-base pH clock (a kinetic switch), bistability and hysteresis between an acid/base state when the initial pH was adjusted by a strong acid, and aperiodic pH oscillations when the initial pH was adjusted by a weak acid in an open reactor. A simple model of the reaction reproduced most of the experimental results and provided insight into the role of self-buffering in the dynamics. This reaction suggests new possibilities in the development of biocompatible feedback to couple to pH-sensitive processes for bioinspired applications in medicine, engineering, or materials science.
14059–14063
Hu, G.
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Pojman, J.A.
d4ab5f67-2edf-48a0-bc95-39f7e10b9b52
Scott, S.K.
5aeb077a-f6af-4662-8b20-b2e0dbf1b4b9
Wrobel, M.M.
b7aeb075-59b8-41e4-9f4e-a9b464e777ee
Taylor, A.F.
08028a29-428d-4732-b6b1-f7a93389b386
18 October 2010
Hu, G.
2d93438f-a743-492a-9cdf-6dd0bacc2341
Pojman, J.A.
d4ab5f67-2edf-48a0-bc95-39f7e10b9b52
Scott, S.K.
5aeb077a-f6af-4662-8b20-b2e0dbf1b4b9
Wrobel, M.M.
b7aeb075-59b8-41e4-9f4e-a9b464e777ee
Taylor, A.F.
08028a29-428d-4732-b6b1-f7a93389b386
Hu, G., Pojman, J.A., Scott, S.K., Wrobel, M.M. and Taylor, A.F.
(2010)
Base-catalyzed feedback in the urea-urease reaction.
Journal of Physical Chemistry B, 114 (44), .
(doi:10.1021/jp106532d).
Abstract
The bell-shaped rate−pH curve coupled to production of base in the urea−urease reaction was utilized to give feedback-driven behavior: an acid-to-base pH clock (a kinetic switch), bistability and hysteresis between an acid/base state when the initial pH was adjusted by a strong acid, and aperiodic pH oscillations when the initial pH was adjusted by a weak acid in an open reactor. A simple model of the reaction reproduced most of the experimental results and provided insight into the role of self-buffering in the dynamics. This reaction suggests new possibilities in the development of biocompatible feedback to couple to pH-sensitive processes for bioinspired applications in medicine, engineering, or materials science.
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Published date: 18 October 2010
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Local EPrints ID: 499563
URI: http://eprints.soton.ac.uk/id/eprint/499563
ISSN: 1520-5207
PURE UUID: 3a9a7296-f5ca-497b-870a-ce89e15b829d
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Date deposited: 25 Mar 2025 18:28
Last modified: 26 Mar 2025 03:14
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Contributors
Author:
G. Hu
Author:
J.A. Pojman
Author:
S.K. Scott
Author:
M.M. Wrobel
Author:
A.F. Taylor
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