Vitamin biosynthetic pathways, the PLP synthase complex, and the potential for targeting protein-protein interaction
Vitamin biosynthetic pathways, the PLP synthase complex, and the potential for targeting protein-protein interaction
Vitamin biosynthetic pathways may provide targets for the development of antiparasitic drugs when absent from mammals or parasitic host organisms. The targeting of a specific biosynthetic route requires that the vitamin in question is essential for the parasite?s survival. In this chapter, several vitamin biosynthetic pathways are discussed as malarial drug targets. Recent advances have been made in the area of vitamin B6 biosynthesis by studying a key multienzyme complex, pyridoxal 5-phosphate (PLP) synthase. Today, complex assembly and ensuing enzyme activation have been very well described, through a combination of X-ray crystallography, calorimetry, homology modeling, and kinetic analyses. The study of protein complexes using these techniques may be valuable for drug design applications, specifically for systems where protein-protein interaction can be targeted.
Interface, Isothermal titration calorimetry, Plasmodium, Protein-protein interaction, Pyridoxal 5-phosphate biosynthesis, Vitamin B6, X-ray structure
251-270
Tews, Ivo
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Sinning, Irmgard
fbc3f199-8a3b-47a6-9ee7-00bfc472e079
21 February 2011
Tews, Ivo
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Sinning, Irmgard
fbc3f199-8a3b-47a6-9ee7-00bfc472e079
Tews, Ivo and Sinning, Irmgard
(2011)
Vitamin biosynthetic pathways, the PLP synthase complex, and the potential for targeting protein-protein interaction.
In,
Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development.
Wiley-VCH Verlag, .
(doi:10.1002/9783527633883.ch13).
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Book Section
Abstract
Vitamin biosynthetic pathways may provide targets for the development of antiparasitic drugs when absent from mammals or parasitic host organisms. The targeting of a specific biosynthetic route requires that the vitamin in question is essential for the parasite?s survival. In this chapter, several vitamin biosynthetic pathways are discussed as malarial drug targets. Recent advances have been made in the area of vitamin B6 biosynthesis by studying a key multienzyme complex, pyridoxal 5-phosphate (PLP) synthase. Today, complex assembly and ensuing enzyme activation have been very well described, through a combination of X-ray crystallography, calorimetry, homology modeling, and kinetic analyses. The study of protein complexes using these techniques may be valuable for drug design applications, specifically for systems where protein-protein interaction can be targeted.
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Published date: 21 February 2011
Keywords:
Interface, Isothermal titration calorimetry, Plasmodium, Protein-protein interaction, Pyridoxal 5-phosphate biosynthesis, Vitamin B6, X-ray structure
Identifiers
Local EPrints ID: 500526
URI: http://eprints.soton.ac.uk/id/eprint/500526
PURE UUID: a7259363-e48f-48e4-b9fb-b822119316e9
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Date deposited: 02 May 2025 16:59
Last modified: 03 May 2025 01:45
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Author:
Irmgard Sinning
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