Genetics and epigenetics in gestational diabetes contributing to type 2 diabetes
Genetics and epigenetics in gestational diabetes contributing to type 2 diabetes
Gestational diabetes mellitus (GDM) is a common pregnancy complication and a risk factor for the subsequent development of type 2 diabetes (T2D) in mothers and of several metabolic diseases in offspring. However, the molecular underpinnings of these risks are not well understood. Genome-wide association studies (GWAS) and epigenetic studies may provide complementary insights into the causal relationships between GDM exposure and maternal/offspring metabolic outcomes. In this review we discuss the potential pathophysiological roles of specific genetic variants and commonly reported differentially methylated loci in GDM development, and their link to the progression to T2D in both the mother and the offspring in later life, pointing to the potential for tailored interventional strategies based on these genetic and epigenetic mechanisms.
DNA methylation, epigenetics, genetics, gestational diabetes mellitus, single-nucleotide polymorphism, type 2 diabetes
Kong, Dewei
43b911f6-afee-4df0-98c1-97069c2d3a56
Kowalik, Olivia
8eac247b-1e52-442b-afd4-ddf524b9ae76
Garratt, Emma
66ddd4cb-19a2-4d08-889b-12f418e6878b
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Chan, Shiao-Yng
3c9d8970-2cc4-430a-86a7-96f6029a5293
Teo, Adrian K.K.
34d2899a-2414-41e1-8a8a-a75e97e649ca
24 April 2025
Kong, Dewei
43b911f6-afee-4df0-98c1-97069c2d3a56
Kowalik, Olivia
8eac247b-1e52-442b-afd4-ddf524b9ae76
Garratt, Emma
66ddd4cb-19a2-4d08-889b-12f418e6878b
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Chan, Shiao-Yng
3c9d8970-2cc4-430a-86a7-96f6029a5293
Teo, Adrian K.K.
34d2899a-2414-41e1-8a8a-a75e97e649ca
Kong, Dewei, Kowalik, Olivia, Garratt, Emma, Godfrey, Keith M., Chan, Shiao-Yng and Teo, Adrian K.K.
(2025)
Genetics and epigenetics in gestational diabetes contributing to type 2 diabetes.
Trends in Endocrinology & Metabolism.
(doi:10.1016/j.tem.2025.03.014).
Abstract
Gestational diabetes mellitus (GDM) is a common pregnancy complication and a risk factor for the subsequent development of type 2 diabetes (T2D) in mothers and of several metabolic diseases in offspring. However, the molecular underpinnings of these risks are not well understood. Genome-wide association studies (GWAS) and epigenetic studies may provide complementary insights into the causal relationships between GDM exposure and maternal/offspring metabolic outcomes. In this review we discuss the potential pathophysiological roles of specific genetic variants and commonly reported differentially methylated loci in GDM development, and their link to the progression to T2D in both the mother and the offspring in later life, pointing to the potential for tailored interventional strategies based on these genetic and epigenetic mechanisms.
Text
Kong and Kowalik et al. revised CLEAN SENT FINAL
- Accepted Manuscript
More information
Accepted/In Press date: 29 March 2025
e-pub ahead of print date: 24 April 2025
Published date: 24 April 2025
Additional Information:
For the purpose of Open Access, the author has applied a Creative Commons Attribution (CC BY) license to any Author Accepted Manuscript version arising from this submission.
Keywords:
DNA methylation, epigenetics, genetics, gestational diabetes mellitus, single-nucleotide polymorphism, type 2 diabetes
Identifiers
Local EPrints ID: 500715
URI: http://eprints.soton.ac.uk/id/eprint/500715
ISSN: 1043-2760
PURE UUID: e4197987-dfe4-43ce-8e8b-d25f82b3ada8
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Date deposited: 12 May 2025 16:33
Last modified: 28 Aug 2025 01:39
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Contributors
Author:
Dewei Kong
Author:
Olivia Kowalik
Author:
Emma Garratt
Author:
Shiao-Yng Chan
Author:
Adrian K.K. Teo
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