The University of Southampton
×
Filter your search:
University of Southampton Institutional Repository

A perspective on muscle phenotyping in musculoskeletal research

A perspective on muscle phenotyping in musculoskeletal research
A perspective on muscle phenotyping in musculoskeletal research

Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genomics of MusculoSkeletal traits Translational Network' (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.

Animals, Humans, Phenotype, Muscle, Skeletal/metabolism, Zebrafish, Mice, Sarcopenia/metabolism, Musculoskeletal Diseases/physiopathology, Osteoporosis/metabolism
1043-2760
478-489
Foessl, Ines
f68432a1-47ea-499f-b7a6-521db3beceeb
Ackert-Bicknell, Cheryl L.
0a3bcd0a-676c-4692-8802-34935050039f
Kague, Erika
b73cb168-403f-4480-8dfc-3fa8e96e8f9a
Laskou, Faidra
3959d6e2-ccfa-4d97-8311-16f27b893365
Jakob, Franz
27375404-93e8-4857-bb72-228d3349fb08
Karasik, David
aa298c9a-b592-46d9-9ed8-cd4d6ffbb27e
Obermayer-Pietsch, Barbara
f366779e-4808-4bf5-bb8e-6523b96656b9
Alonso, Nerea
2b42078f-ea96-49c1-9c1c-d8ed18ee4ac9
Bjørnerem, Åshild
5aff4bcb-cd1c-4d7d-9c36-e4f39f0426fa
Brandi, Maria Luisa
b42820a8-1622-4a0d-8f9b-3f53f2e90180
Busse, Björn
b6e43ffc-c839-42c6-be79-3e8ef2cb3a8e
Calado, Ângelo
8591d038-e933-4644-b5e3-ed87a426b70a
Cebi, Alper Han
9f942e48-6cd7-401b-abd1-36c6e16cd655
Christou, Maria
e717dcda-45c7-4ff7-aeb7-f6f1fe03690d
Curran, Kathleen M.
39dc227e-7a7e-4002-9793-d946993ec1d2
Hald, Jannie Dahl
f0d42611-a2f9-46bf-b4ff-aaa6dde14590
Semeraro, Maria Donatella
358c7814-6c58-4cab-97cc-48ae4c4d3aef
Douni, Eleni
81f84bed-e888-49d8-92c3-d7857ce44caa
Duncan, Emma L.
881b5a19-428d-4a07-97c0-59492e814f56
Duran, Ivan
d3c25bf5-7afc-42ae-8f99-583466044878
Formosa, Melissa M.
0aa68d84-ad13-435e-9b29-829964352d22
Gabet, Yankel
7be5579c-87b1-4f03-9c43-b1c1aa6f9068
Ghatan, Samuel
f3bd14b8-1abc-4e70-8d08-393c16fbfab6
Gkitakou, Artemis
c950c014-4ca7-4632-bbd8-4e6c26badee6
Hassler, Eva Maria
6e46b938-b498-4716-bd13-d73e70a32373
Högler, Wolfgang
08b8f77c-d6b9-4f2f-b9ec-31e1976ed439
Heino, Terhi J.
91fffc22-5569-49ff-9627-466c66bee013
Hendrickx, Gretl
107cacf8-6a97-426b-b817-e5fbe55772e5
Khashayar, Patricia
3ae08833-13ad-4848-83bd-e47f46119143
Kiel, Douglas P.
ff4d761f-9e48-415b-aae2-0c45381fd05f
Koromani, Fjorda
e7c70829-d1de-459c-b5ab-9fbd4720d8b5
Langdahl, Bente
ebedcef0-9a49-4c9f-a9f7-d1e867138ac2
Lopes, Philippe
9567e4dd-e22b-48d7-acb2-a1c03e071fd0
Mäkitie, Outi
bd5e8636-78a2-49f4-b71f-711bc1c15fb3
Maurizi, Antonio
a532d8e1-6fa6-4087-80d5-91241eaf7937
Medina-Gomez, Carolina
f2383784-89c7-45ef-9904-3be3923c4446
Ntzani, Evangelia
1fe5a0e3-0233-4868-9adb-4239f9d28795
Ohlsson, Claes
98168752-6ef1-40c6-b873-9361cc99358b
Prijatelj, Vid
00e60ada-ac6e-441f-a35d-e4a49d24c1c0
Rabionet, Raquel
82dfa3f0-8e7f-4d96-91cc-95264fd91407
Reppe, Sjur
25b85251-c7d5-4b59-9550-336b3f277ef9
Rivadeneira, Fernando
8441b9d3-6d8e-4b33-8827-dd70d80db200
Roshchupkin, Gennady
d4706a39-7368-4d28-a757-b36bfac24558
Sharma, Neha
c5c663b2-86e4-4e3c-8f56-c28351419587
Søe, Kent
34427bcc-1e8b-4bda-a0cd-39b140b6b6b3
Styrkarsdottir, Unnur
ab39a288-ef2a-4607-8978-8a24da369125
Szulc, Pavel
be7be16f-2b46-4929-b36e-fc2a1a6967cd
Teti, Anna
30b62460-381a-4021-b5bf-a6ca6ec2d29d
Tobias, Jon
b41958fb-62c0-4d28-a93e-008a78681817
Valjevac, Amina
c66185e7-cf1f-4b1e-bdb5-555c106e0e43
et al
Foessl, Ines
f68432a1-47ea-499f-b7a6-521db3beceeb
Ackert-Bicknell, Cheryl L.
0a3bcd0a-676c-4692-8802-34935050039f
Kague, Erika
b73cb168-403f-4480-8dfc-3fa8e96e8f9a
Laskou, Faidra
3959d6e2-ccfa-4d97-8311-16f27b893365
Jakob, Franz
27375404-93e8-4857-bb72-228d3349fb08
Karasik, David
aa298c9a-b592-46d9-9ed8-cd4d6ffbb27e
Obermayer-Pietsch, Barbara
f366779e-4808-4bf5-bb8e-6523b96656b9
Alonso, Nerea
2b42078f-ea96-49c1-9c1c-d8ed18ee4ac9
Bjørnerem, Åshild
5aff4bcb-cd1c-4d7d-9c36-e4f39f0426fa
Brandi, Maria Luisa
b42820a8-1622-4a0d-8f9b-3f53f2e90180
Busse, Björn
b6e43ffc-c839-42c6-be79-3e8ef2cb3a8e
Calado, Ângelo
8591d038-e933-4644-b5e3-ed87a426b70a
Cebi, Alper Han
9f942e48-6cd7-401b-abd1-36c6e16cd655
Christou, Maria
e717dcda-45c7-4ff7-aeb7-f6f1fe03690d
Curran, Kathleen M.
39dc227e-7a7e-4002-9793-d946993ec1d2
Hald, Jannie Dahl
f0d42611-a2f9-46bf-b4ff-aaa6dde14590
Semeraro, Maria Donatella
358c7814-6c58-4cab-97cc-48ae4c4d3aef
Douni, Eleni
81f84bed-e888-49d8-92c3-d7857ce44caa
Duncan, Emma L.
881b5a19-428d-4a07-97c0-59492e814f56
Duran, Ivan
d3c25bf5-7afc-42ae-8f99-583466044878
Formosa, Melissa M.
0aa68d84-ad13-435e-9b29-829964352d22
Gabet, Yankel
7be5579c-87b1-4f03-9c43-b1c1aa6f9068
Ghatan, Samuel
f3bd14b8-1abc-4e70-8d08-393c16fbfab6
Gkitakou, Artemis
c950c014-4ca7-4632-bbd8-4e6c26badee6
Hassler, Eva Maria
6e46b938-b498-4716-bd13-d73e70a32373
Högler, Wolfgang
08b8f77c-d6b9-4f2f-b9ec-31e1976ed439
Heino, Terhi J.
91fffc22-5569-49ff-9627-466c66bee013
Hendrickx, Gretl
107cacf8-6a97-426b-b817-e5fbe55772e5
Khashayar, Patricia
3ae08833-13ad-4848-83bd-e47f46119143
Kiel, Douglas P.
ff4d761f-9e48-415b-aae2-0c45381fd05f
Koromani, Fjorda
e7c70829-d1de-459c-b5ab-9fbd4720d8b5
Langdahl, Bente
ebedcef0-9a49-4c9f-a9f7-d1e867138ac2
Lopes, Philippe
9567e4dd-e22b-48d7-acb2-a1c03e071fd0
Mäkitie, Outi
bd5e8636-78a2-49f4-b71f-711bc1c15fb3
Maurizi, Antonio
a532d8e1-6fa6-4087-80d5-91241eaf7937
Medina-Gomez, Carolina
f2383784-89c7-45ef-9904-3be3923c4446
Ntzani, Evangelia
1fe5a0e3-0233-4868-9adb-4239f9d28795
Ohlsson, Claes
98168752-6ef1-40c6-b873-9361cc99358b
Prijatelj, Vid
00e60ada-ac6e-441f-a35d-e4a49d24c1c0
Rabionet, Raquel
82dfa3f0-8e7f-4d96-91cc-95264fd91407
Reppe, Sjur
25b85251-c7d5-4b59-9550-336b3f277ef9
Rivadeneira, Fernando
8441b9d3-6d8e-4b33-8827-dd70d80db200
Roshchupkin, Gennady
d4706a39-7368-4d28-a757-b36bfac24558
Sharma, Neha
c5c663b2-86e4-4e3c-8f56-c28351419587
Søe, Kent
34427bcc-1e8b-4bda-a0cd-39b140b6b6b3
Styrkarsdottir, Unnur
ab39a288-ef2a-4607-8978-8a24da369125
Szulc, Pavel
be7be16f-2b46-4929-b36e-fc2a1a6967cd
Teti, Anna
30b62460-381a-4021-b5bf-a6ca6ec2d29d
Tobias, Jon
b41958fb-62c0-4d28-a93e-008a78681817
Valjevac, Amina
c66185e7-cf1f-4b1e-bdb5-555c106e0e43

Foessl, Ines, Ackert-Bicknell, Cheryl L. and Kague, Erika , et al (2024) A perspective on muscle phenotyping in musculoskeletal research. Trends in Endocrinology and Metabolism: TEM, 35 (6), 478-489. (doi:10.1016/j.tem.2024.01.004).

Record type: Review

Abstract

Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genomics of MusculoSkeletal traits Translational Network' (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.

Text
1-s2.0-S1043276024000183-main - Version of Record
Available under License Creative Commons Attribution.
Download (1MB)

More information

e-pub ahead of print date: 28 March 2024
Published date: 10 June 2024
Keywords: Animals, Humans, Phenotype, Muscle, Skeletal/metabolism, Zebrafish, Mice, Sarcopenia/metabolism, Musculoskeletal Diseases/physiopathology, Osteoporosis/metabolism

Identifiers

Local EPrints ID: 500873
URI: http://eprints.soton.ac.uk/id/eprint/500873
DOI: doi:10.1016/j.tem.2024.01.004
ISSN: 1043-2760
PURE UUID: f41bfcc5-5b67-4fbc-bda0-7c92dd556024
ORCID for Faidra Laskou: ORCID iD orcid.org/0000-0002-8481-6343

Catalogue record

Date deposited: 14 May 2025 16:53
Last modified: 16 Oct 2025 17:54

Export record

Altmetrics

Contributors

Author: Ines Foessl
Author: Cheryl L. Ackert-Bicknell
Author: Erika Kague
Author: Faidra Laskou ORCID iD
Author: Franz Jakob
Author: David Karasik
Author: Barbara Obermayer-Pietsch
Author: Nerea Alonso
Author: Åshild Bjørnerem
Author: Maria Luisa Brandi
Author: Björn Busse
Author: Ângelo Calado
Author: Alper Han Cebi
Author: Maria Christou
Author: Kathleen M. Curran
Author: Jannie Dahl Hald
Author: Maria Donatella Semeraro
Author: Eleni Douni
Author: Emma L. Duncan
Author: Ivan Duran
Author: Melissa M. Formosa
Author: Yankel Gabet
Author: Samuel Ghatan
Author: Artemis Gkitakou
Author: Eva Maria Hassler
Author: Wolfgang Högler
Author: Terhi J. Heino
Author: Gretl Hendrickx
Author: Patricia Khashayar
Author: Douglas P. Kiel
Author: Fjorda Koromani
Author: Bente Langdahl
Author: Philippe Lopes
Author: Outi Mäkitie
Author: Antonio Maurizi
Author: Carolina Medina-Gomez
Author: Evangelia Ntzani
Author: Claes Ohlsson
Author: Vid Prijatelj
Author: Raquel Rabionet
Author: Sjur Reppe
Author: Fernando Rivadeneira
Author: Gennady Roshchupkin
Author: Neha Sharma
Author: Kent Søe
Author: Unnur Styrkarsdottir
Author: Pavel Szulc
Author: Anna Teti
Author: Jon Tobias
Author: Amina Valjevac
Corporate Author: et al

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Library staff additional information
Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×