Assessment of fracture risk with FRAX and FRAXplus
Assessment of fracture risk with FRAX and FRAXplus
FRAX®, a risk calculator that provides individualized 10-year probabilities of hip and major osteoporotic fracture, has been widely used for fracture risk assessment since its launch in 2008. It is now incorporated into very many guidelines worldwide to inform osteoporosis management. In this review, we explore the development of FRAX and how it enhances fracture risk prediction as compared to use of bone mineral density alone, as well as approaches to utilizing FRAX in determining intervention and assessment thresholds. We also discuss the limitations of FRAX and the arithmetic adjustments that have been proposed to address these. The introduction of FRAXplus® includes these adjustments on a web-based platform for ease of application to enhance treatment decisions in osteoporosis.
Humans, Risk Assessment/methods, Osteoporotic Fractures/etiology, Bone Density, Osteoporosis/epidemiology, Hip Fractures/epidemiology
363-373
Tan, Teck H.A.
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Johansson, Helena
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Harvey, Nicholas C.
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Lorentzon, Mattias
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Kanis, John A.
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McCloskey, Eugene
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Schini, Marian
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2024
Tan, Teck H.A.
28b2350f-f434-4cbf-a78e-9847f3e28d2d
Johansson, Helena
04f12338-4dd1-437b-b9bc-e0884130c215
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Lorentzon, Mattias
9d78ed25-2b0c-46c5-a2db-a8b246af0956
Kanis, John A.
f1621d8d-8afb-4d97-9679-2165d88a344d
McCloskey, Eugene
3a2fac33-b400-4ae3-a212-04c3c3d2a517
Schini, Marian
046f4310-e359-43d7-bcdf-f9e4f5aa516e
Tan, Teck H.A., Johansson, Helena, Harvey, Nicholas C., Lorentzon, Mattias, Kanis, John A., McCloskey, Eugene and Schini, Marian
(2024)
Assessment of fracture risk with FRAX and FRAXplus.
Gaceta medica de Mexico, 160 (4), .
(doi:10.24875/GMM.24000107).
Abstract
FRAX®, a risk calculator that provides individualized 10-year probabilities of hip and major osteoporotic fracture, has been widely used for fracture risk assessment since its launch in 2008. It is now incorporated into very many guidelines worldwide to inform osteoporosis management. In this review, we explore the development of FRAX and how it enhances fracture risk prediction as compared to use of bone mineral density alone, as well as approaches to utilizing FRAX in determining intervention and assessment thresholds. We also discuss the limitations of FRAX and the arithmetic adjustments that have been proposed to address these. The introduction of FRAXplus® includes these adjustments on a web-based platform for ease of application to enhance treatment decisions in osteoporosis.
Text
gmm-uk_24_160_4_363-373
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More information
Accepted/In Press date: 9 April 2024
Published date: 2024
Additional Information:
Copyright: © 2024 Permanyer.
Keywords:
Humans, Risk Assessment/methods, Osteoporotic Fractures/etiology, Bone Density, Osteoporosis/epidemiology, Hip Fractures/epidemiology
Identifiers
Local EPrints ID: 500874
URI: http://eprints.soton.ac.uk/id/eprint/500874
ISSN: 0016-3813
PURE UUID: fd91dd17-2d6c-4ae6-96d0-68e5e0005fa5
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Date deposited: 14 May 2025 16:54
Last modified: 22 Aug 2025 01:52
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Contributors
Author:
Teck H.A. Tan
Author:
Helena Johansson
Author:
Mattias Lorentzon
Author:
John A. Kanis
Author:
Eugene McCloskey
Author:
Marian Schini
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