Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential
Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential
The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.
Nefzger, Christian M.
a7cb9192-20e8-4c16-8b95-819f48e44a78
Jardé, Thierry
ad4eabd5-83d4-4d79-8d32-92e1e2cee296
Srivastava, Akanksha
1746cdcf-7426-4c0c-a420-130ee6b7ebc4
Rackham, Owen J.L.
8122eb1f-6e9f-4da5-90e1-ce108ccbbcbf
16 June 2022
Nefzger, Christian M.
a7cb9192-20e8-4c16-8b95-819f48e44a78
Jardé, Thierry
ad4eabd5-83d4-4d79-8d32-92e1e2cee296
Srivastava, Akanksha
1746cdcf-7426-4c0c-a420-130ee6b7ebc4
Rackham, Owen J.L.
8122eb1f-6e9f-4da5-90e1-ce108ccbbcbf
Nefzger, Christian M., Jardé, Thierry and Srivastava, Akanksha
,
et al.
(2022)
Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential.
NPJ Regenerative medicine, 7, [31].
(doi:10.1038/s41536-022-00226-7).
Abstract
The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.
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s41536-022-00226-7
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Accepted/In Press date: 25 April 2022
Published date: 16 June 2022
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Local EPrints ID: 501100
URI: http://eprints.soton.ac.uk/id/eprint/501100
ISSN: 2057-3995
PURE UUID: 4174dcae-5d45-4bd3-9540-de767a46c052
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Date deposited: 23 May 2025 16:49
Last modified: 22 Aug 2025 02:30
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Author:
Christian M. Nefzger
Author:
Thierry Jardé
Author:
Akanksha Srivastava
Corporate Author: et al.
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