Investigating the antimicrobial activity of 1-heteroaryl benzotriazole silver compounds
Investigating the antimicrobial activity of 1-heteroaryl benzotriazole silver compounds
Five (1–5) Ag(I) compounds, derived from different N,N′-bidentate 1-heteroaryl benzotriazole ligands, were synthesised and characterised using SXRD, IR, UV-Vis, elemental analysis, ESI-MS, and NMR. Variations in ligands and counter-anions produced distinct structures and morphologies. Preliminary antimicrobial testing at the micromolar level, in DMSO, revealed that only compound 2, based on 1-(2-pyridyl)benzotriazole and triflate anion, exhibited interesting antimicrobial properties, thus marking the introduction of a new class of Ag(I) compounds in medicinal inorganic chemistry.
11431-11440
Elzein, Ahmed
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Al Jomeh, Ghadah Abdullah S.
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Tizzard, Graham J.
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Coles, Simon J.
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Banti, Christina N.
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Hadjikakou, Sotiris K.
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Kostakis, George E.
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11 April 2025
Elzein, Ahmed
5f3f3196-f907-46c0-a5b3-f0268887babe
Al Jomeh, Ghadah Abdullah S.
eb43dfca-cc79-47f7-a396-05127563b50d
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Banti, Christina N.
2db920dc-662a-4983-abe1-7c0da32e432b
Hadjikakou, Sotiris K.
ad8d440e-4407-4b18-a731-66091e9f806d
Kostakis, George E.
dd72c724-c82e-4891-aa68-ccdb42cc6cb8
Elzein, Ahmed, Al Jomeh, Ghadah Abdullah S., Tizzard, Graham J., Coles, Simon J., Banti, Christina N., Hadjikakou, Sotiris K. and Kostakis, George E.
(2025)
Investigating the antimicrobial activity of 1-heteroaryl benzotriazole silver compounds.
RSC Advances, 15 (15), .
(doi:10.1039/D5RA01072A).
Abstract
Five (1–5) Ag(I) compounds, derived from different N,N′-bidentate 1-heteroaryl benzotriazole ligands, were synthesised and characterised using SXRD, IR, UV-Vis, elemental analysis, ESI-MS, and NMR. Variations in ligands and counter-anions produced distinct structures and morphologies. Preliminary antimicrobial testing at the micromolar level, in DMSO, revealed that only compound 2, based on 1-(2-pyridyl)benzotriazole and triflate anion, exhibited interesting antimicrobial properties, thus marking the introduction of a new class of Ag(I) compounds in medicinal inorganic chemistry.
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Accepted/In Press date: 29 March 2025
e-pub ahead of print date: 11 April 2025
Published date: 11 April 2025
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Local EPrints ID: 501280
URI: http://eprints.soton.ac.uk/id/eprint/501280
ISSN: 2046-2069
PURE UUID: 50e7dac6-fec1-48d1-8ae7-73f9bbf04d28
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Date deposited: 28 May 2025 16:42
Last modified: 03 Sep 2025 01:38
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Contributors
Author:
Ahmed Elzein
Author:
Ghadah Abdullah S. Al Jomeh
Author:
Christina N. Banti
Author:
Sotiris K. Hadjikakou
Author:
George E. Kostakis
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