The University of Southampton
University of Southampton Institutional Repository

Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder

Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder
Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder
BACKGROUND: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed "default-mode" network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. METHODS: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age- and sex-matched healthy volunteers. RESULTS: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered at x = 8, y = 7, z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p < .0004, corrected). Secondary analyses revealed an extensive pattern of ADHD-related decreases in connectivity between precuneus and other default-mode network components, including ventromedial prefrontal cortex (p < 3 x 10(-11), corrected) and portions of posterior cingulate (p < .02, corrected). CONCLUSIONS: Together with prior unbiased anatomic evidence of posterior volumetric abnormalities, our findings suggest that the long-range connections linking dorsal anterior cingulate to posterior cingulate and precuneus should be considered as a candidate locus of dysfunction in ADHD.
adhd, anterior cingulate cortex, default-mode network, functional magnetic resonance imaging, precuneus, posterior cingulate cortex
0006-3223
332-337
Castellanos, F. Xavier
699a8e5d-77f7-41dd-8dba-50f2dece7dd8
Margulies, Daniel S.
8777af4b-11cb-481d-b75c-a3a2032bdf4f
Kelly, Clare
f33af47b-6b5d-4306-a280-7db9b4612508
Uddin, Lucida Q.
071be526-f81a-46ae-9513-6a64796eeb0c
Ghaffari, Manley
38276248-0b06-474b-a80a-82f103560188
Kirsch, Andrew
abc32022-115c-4426-9812-ad6c3ae99a24
Shaw, David
6a7fee07-08e4-4b9a-a547-1e8ce91a3ef2
Shehzad, Zarrar
c66bee14-b204-4aa8-8eb3-b33b99e83ec8
Di Martino, Adriana
86328f4a-566d-4ff5-9b6d-209801a0632e
Biswal, Bharat
e79a1f9d-c0ef-4342-b31a-287d9575a55c
Sonuga-Barke, Edmund J.S.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Rotrosen, John
6fe28fc9-8411-4f4b-9a0e-3023ae5324c5
Adler, Lenard A.
16b4b4aa-ec18-4290-b752-15eb4132f4f8
Milham, Michael P.
e95a9d22-6154-47a9-a26f-e27836df8675
Castellanos, F. Xavier
699a8e5d-77f7-41dd-8dba-50f2dece7dd8
Margulies, Daniel S.
8777af4b-11cb-481d-b75c-a3a2032bdf4f
Kelly, Clare
f33af47b-6b5d-4306-a280-7db9b4612508
Uddin, Lucida Q.
071be526-f81a-46ae-9513-6a64796eeb0c
Ghaffari, Manley
38276248-0b06-474b-a80a-82f103560188
Kirsch, Andrew
abc32022-115c-4426-9812-ad6c3ae99a24
Shaw, David
6a7fee07-08e4-4b9a-a547-1e8ce91a3ef2
Shehzad, Zarrar
c66bee14-b204-4aa8-8eb3-b33b99e83ec8
Di Martino, Adriana
86328f4a-566d-4ff5-9b6d-209801a0632e
Biswal, Bharat
e79a1f9d-c0ef-4342-b31a-287d9575a55c
Sonuga-Barke, Edmund J.S.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Rotrosen, John
6fe28fc9-8411-4f4b-9a0e-3023ae5324c5
Adler, Lenard A.
16b4b4aa-ec18-4290-b752-15eb4132f4f8
Milham, Michael P.
e95a9d22-6154-47a9-a26f-e27836df8675

Castellanos, F. Xavier, Margulies, Daniel S., Kelly, Clare, Uddin, Lucida Q., Ghaffari, Manley, Kirsch, Andrew, Shaw, David, Shehzad, Zarrar, Di Martino, Adriana, Biswal, Bharat, Sonuga-Barke, Edmund J.S., Rotrosen, John, Adler, Lenard A. and Milham, Michael P. (2008) Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. [in special issue: Impulse Control: Aggression, Addiction, and Attention Deficits] Biological Psychiatry, 63 (3), 332-337. (doi:10.1016/j.biopsych.2007.06.025). (PMID:17888409)

Record type: Article

Abstract

BACKGROUND: Pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) have focused on frontal-striatal circuitry with alternative hypotheses relatively unexplored. On the basis of evidence that negative interactions between frontal foci involved in cognitive control and the non-goal-directed "default-mode" network prevent attentional lapses, we hypothesized abnormalities in functional connectivity of these circuits in ADHD. METHODS: Resting-state blood oxygen level-dependent functional magnetic resonance imaging (fMRI) scans were obtained at 3.0-Tesla in 20 adults with ADHD and 20 age- and sex-matched healthy volunteers. RESULTS: Examination of healthy control subjects verified presence of an antiphasic or negative relationship between activity in dorsal anterior cingulate cortex (centered at x = 8, y = 7, z = 38) and in default-mode network components. Group analyses revealed ADHD-related compromises in this relationship, with decreases in the functional connectivity between the anterior cingulate and precuneus/posterior cingulate cortex regions (p < .0004, corrected). Secondary analyses revealed an extensive pattern of ADHD-related decreases in connectivity between precuneus and other default-mode network components, including ventromedial prefrontal cortex (p < 3 x 10(-11), corrected) and portions of posterior cingulate (p < .02, corrected). CONCLUSIONS: Together with prior unbiased anatomic evidence of posterior volumetric abnormalities, our findings suggest that the long-range connections linking dorsal anterior cingulate to posterior cingulate and precuneus should be considered as a candidate locus of dysfunction in ADHD.

Full text not available from this repository.

More information

e-pub ahead of print date: 21 September 2007
Published date: 1 February 2008
Keywords: adhd, anterior cingulate cortex, default-mode network, functional magnetic resonance imaging, precuneus, posterior cingulate cortex
Organisations: Clinical Neurosciences

Identifiers

Local EPrints ID: 50138
URI: https://eprints.soton.ac.uk/id/eprint/50138
ISSN: 0006-3223
PURE UUID: faf85300-8da6-494b-b43d-b034739b3904

Catalogue record

Date deposited: 30 Jan 2008
Last modified: 13 Mar 2019 20:52

Export record

Altmetrics

Contributors

Author: F. Xavier Castellanos
Author: Daniel S. Margulies
Author: Clare Kelly
Author: Lucida Q. Uddin
Author: Manley Ghaffari
Author: Andrew Kirsch
Author: David Shaw
Author: Zarrar Shehzad
Author: Adriana Di Martino
Author: Bharat Biswal
Author: Edmund J.S. Sonuga-Barke
Author: John Rotrosen
Author: Lenard A. Adler
Author: Michael P. Milham

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×