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A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16

A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16
A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16
As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth edition combined type attention deficit hyperactivity disorder (ADHD) proband–sibling pairs. No linkage was observed on the most established ADHD-linked genomic regions of 5p and 17p. We found suggestive linkage signals on chromosomes 9 and 16, respectively, with the highest multipoint nonparametric linkage signal on chromosome 16q23 at 99 cM (log of the odds, LOD=3.1) overlapping data published from the previous UCLA (University of California, Los Angeles) (LOD>1, 95 cM) and Dutch (LOD>1, 100 cM) studies. The second highest peak in this study was on chromosome 9q22 at 90 cM (LOD=2.13); both the previous UCLA and German studies also found some evidence of linkage at almost the same location (UCLA LOD=1.45 at 93 cM; German LOD=0.68 at 100 cM). The overlap of these two main peaks with previous findings suggests that loci linked to ADHD may lie within these regions. Meta-analysis or reanalysis of the raw data of all the available ADHD linkage scan data may help to clarify whether these represent true linked loci.
adhd, affected sib pairs, linkage
1359-4184
514-521
Asherson, P.
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Zhou, K.
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Franke, B.
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Boer, F.
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Asherson, P.
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Zhou, K.
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Anney, R.J.L.
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Franke, B.
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Buitelaar, J.
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Gill, M.
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Altink, M.
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Boer, F.
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Brookes, K.
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Buschgens, C.
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Butler, L.
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Cambell, D.
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Chen, W.
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Christiansen, H.
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Feldman, L.
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Fleischman, K.
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Fliers, E.
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Howe-Forbes, R.
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Goldfarb, A.
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Heise, A.
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Lubetzki, I.
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Psychogiou, L.
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Weeks, A.
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Xu, X.
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Banaschewski, T.
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Sonuga-Barke, E.
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Roeyers, H.
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Rothenberger, A.
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Sergeant, J.
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Steinhausen, H-C
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Taylor, E.
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Faraone, S.V.
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Asherson, P., Zhou, K., Anney, R.J.L., Franke, B., Buitelaar, J., Ebstein, R., Gill, M., Altink, M., Arnold, R., Boer, F., Brookes, K., Buschgens, C., Butler, L., Cambell, D., Chen, W., Christiansen, H., Feldman, L., Fleischman, K., Fliers, E., Howe-Forbes, R., Goldfarb, A., Heise, A., Gabriëls, I., Johansson, L., Lubetzki, I., Marco, R., Medad, S., Minderaa, R., Mulas, F., Müller, U., Mulligan, A., Neale, B., Rijsdijk, F., Rabin, K., Rommelse, N., Sethna, V., Sorohan, J., Uebel, H., Psychogiou, L., Weeks, A., Barrett, R., Xu, X., Banaschewski, T., Sonuga-Barke, E., Eisenberg, J., Manor, I., Miranda, A., Oades, R.D., Roeyers, H., Rothenberger, A., Sergeant, J., Steinhausen, H-C, Taylor, E. and Faraone, S.V. (2008) A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16. Molecular Psychiatry, 13 (5), 514-521. (doi:10.1038/sj.mp.4002140).

Record type: Article

Abstract

As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth edition combined type attention deficit hyperactivity disorder (ADHD) proband–sibling pairs. No linkage was observed on the most established ADHD-linked genomic regions of 5p and 17p. We found suggestive linkage signals on chromosomes 9 and 16, respectively, with the highest multipoint nonparametric linkage signal on chromosome 16q23 at 99 cM (log of the odds, LOD=3.1) overlapping data published from the previous UCLA (University of California, Los Angeles) (LOD>1, 95 cM) and Dutch (LOD>1, 100 cM) studies. The second highest peak in this study was on chromosome 9q22 at 90 cM (LOD=2.13); both the previous UCLA and German studies also found some evidence of linkage at almost the same location (UCLA LOD=1.45 at 93 cM; German LOD=0.68 at 100 cM). The overlap of these two main peaks with previous findings suggests that loci linked to ADHD may lie within these regions. Meta-analysis or reanalysis of the raw data of all the available ADHD linkage scan data may help to clarify whether these represent true linked loci.

Full text not available from this repository.

More information

Published date: May 2008
Additional Information: Advance online publication
Keywords: adhd, affected sib pairs, linkage

Identifiers

Local EPrints ID: 50140
URI: https://eprints.soton.ac.uk/id/eprint/50140
ISSN: 1359-4184
PURE UUID: 241515ea-1e72-4297-a800-dc956c75b7f8

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Date deposited: 30 Jan 2008
Last modified: 13 Mar 2019 20:52

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Contributors

Author: P. Asherson
Author: K. Zhou
Author: R.J.L. Anney
Author: B. Franke
Author: J. Buitelaar
Author: R. Ebstein
Author: M. Gill
Author: M. Altink
Author: R. Arnold
Author: F. Boer
Author: K. Brookes
Author: C. Buschgens
Author: L. Butler
Author: D. Cambell
Author: W. Chen
Author: H. Christiansen
Author: L. Feldman
Author: K. Fleischman
Author: E. Fliers
Author: R. Howe-Forbes
Author: A. Goldfarb
Author: A. Heise
Author: I. Gabriëls
Author: L. Johansson
Author: I. Lubetzki
Author: R. Marco
Author: S. Medad
Author: R. Minderaa
Author: F. Mulas
Author: U. Müller
Author: A. Mulligan
Author: B. Neale
Author: F. Rijsdijk
Author: K. Rabin
Author: N. Rommelse
Author: V. Sethna
Author: J. Sorohan
Author: H. Uebel
Author: L. Psychogiou
Author: A. Weeks
Author: R. Barrett
Author: X. Xu
Author: T. Banaschewski
Author: E. Sonuga-Barke
Author: J. Eisenberg
Author: I. Manor
Author: A. Miranda
Author: R.D. Oades
Author: H. Roeyers
Author: A. Rothenberger
Author: J. Sergeant
Author: H-C Steinhausen
Author: E. Taylor
Author: S.V. Faraone

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