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Filtering property of myelinated internode can change neural information representability and might trigger a compensatory action during demyelination

Filtering property of myelinated internode can change neural information representability and might trigger a compensatory action during demyelination
Filtering property of myelinated internode can change neural information representability and might trigger a compensatory action during demyelination
In this paper, for the first time, we showed that an Internode Segment (INS) of a myelinated axon acts as a lowpass filter, and its filter characteristics depend on the number of myelin turns. Consequently, we showed how the representability of a neural signal could be altered with myelin loss in pathological conditions involving demyelinating diseases. Contrary to the traditionally held viewpoint that myelin geometry of an INS is optimised for maximising Conduction Velocity (CV) of Action Potential (AP), our theory provides an alternative viewpoint that myelin geometry of an INS is optimised for maximizing representability of the stimuli a fibre is meant to carry. Subsequently, we show that this new viewpoint could explain hitherto unexplained experimentally observed phenomena such as, shortening of INS length during demyelination and remyelination, and non-uniform distribution of INS in the central nervous system fibres and associated changes in diameter of nodes of ranvier along an axon. Finally, our theory indicates that a compensatory action could take place during demyelination up to a certain number of loss of myelin turns to preserve the neural signal representability by simultaneous linear scaling of the length of an INS and the inner radius of the fibre.
Computational biology and bioinformatics,, Neuroscience, Physiology
2045-2322
Das, Sarbani
2b15e18e-f948-404f-bc4d-d61b32ef7491
Maharatna, Koushik
93bef0a2-e011-4622-8c56-5447da4cd5dd
Das, Sarbani
2b15e18e-f948-404f-bc4d-d61b32ef7491
Maharatna, Koushik
93bef0a2-e011-4622-8c56-5447da4cd5dd

Das, Sarbani and Maharatna, Koushik (2023) Filtering property of myelinated internode can change neural information representability and might trigger a compensatory action during demyelination. Scientific Reports, 13 (22227). (doi:10.1038/s41598-023-49208-9).

Record type: Article

Abstract

In this paper, for the first time, we showed that an Internode Segment (INS) of a myelinated axon acts as a lowpass filter, and its filter characteristics depend on the number of myelin turns. Consequently, we showed how the representability of a neural signal could be altered with myelin loss in pathological conditions involving demyelinating diseases. Contrary to the traditionally held viewpoint that myelin geometry of an INS is optimised for maximising Conduction Velocity (CV) of Action Potential (AP), our theory provides an alternative viewpoint that myelin geometry of an INS is optimised for maximizing representability of the stimuli a fibre is meant to carry. Subsequently, we show that this new viewpoint could explain hitherto unexplained experimentally observed phenomena such as, shortening of INS length during demyelination and remyelination, and non-uniform distribution of INS in the central nervous system fibres and associated changes in diameter of nodes of ranvier along an axon. Finally, our theory indicates that a compensatory action could take place during demyelination up to a certain number of loss of myelin turns to preserve the neural signal representability by simultaneous linear scaling of the length of an INS and the inner radius of the fibre.

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Accepted/In Press date: 5 December 2023
Published date: 14 December 2023
Keywords: Computational biology and bioinformatics,, Neuroscience, Physiology

Identifiers

Local EPrints ID: 501497
URI: http://eprints.soton.ac.uk/id/eprint/501497
ISSN: 2045-2322
PURE UUID: ea4219b3-c3fb-404c-b7e3-2e04d63ef059
ORCID for Koushik Maharatna: ORCID iD orcid.org/0000-0001-6518-2755

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Date deposited: 02 Jun 2025 17:02
Last modified: 03 Jun 2025 01:42

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Contributors

Author: Sarbani Das
Author: Koushik Maharatna ORCID iD

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