Associations of markers of inflammatory dtatus and adiposity with bone phenotype at age 60-64 years: findings from the MRC National Survey of Health and Development
Associations of markers of inflammatory dtatus and adiposity with bone phenotype at age 60-64 years: findings from the MRC National Survey of Health and Development
This study investigated associations between markers of inflammatory status and adiposity (interleukin-6 [IL-6], adiponectin and leptin) and measures of bone phenotype and fractures. The Medical Research Council (MRC) National Survey of Health and Development (NSHD) is a British birth cohort study. Participants (born during the same week in 1946) with complete data on DXA and pQCT parameters, markers of inflammatory status and adiposity, and potential confounders (498 men and 474 women) were included in cross-sectional analyses. At age 60–64 years, bone phenotype was assessed by DXA and pQCT. Fractures were self-reported at ages 60–64 and 68–70 years. Multiple linear regression was used to determine associations of IL-6, adiponectin and leptin with bone phenotype (adjusted for fat and lean mass and lifestyle confounders). Standard deviation (SD) differences in outcomes per SD increases in exposures were estimated. Higher IL-6 levels were associated with lower total volumetric bone mineral density (vBMD) (− 0.10[− 0.19, 0.00]) in men, and higher areal BMD (aBMD) at the spine (0.12[0.03, 0.22]) and whole body (0.11[0.01, 0.20]) in women. Higher levels of adiponectin were associated with lower aBMD and trabecular vBMD. In women, higher leptin levels were associated with higher cortical vBMD (0.11[0.02, 0.20]). Higher adiponectin was associated with moderately increased odds of having a fragility fracture during adulthood in women (OR 1.16 [95% CI 0.94, 1.43, p = 0.18]). Our results highlight non-mechanical associations between markers of inflammatory status and adiposity with BMD and, in women, fractures. Ensuring inflammaging is minimised may be important in healthy bone ageing.
Dual energy X-ray absorptiometry, Peripheral quantitative computed tomography, Ageing, Bone mineral density, Inflammation, Body composition
Durdin, Ruth
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Pearse, Camille
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Kuh, Diana
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Cooper, Rachel
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Dennison, Elaine M.
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Cooper, Cyrus
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Ward, Kate A.
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6 May 2025
Durdin, Ruth
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Pearse, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Kuh, Diana
4f3b51aa-21a0-4d68-be14-e1ed75448aaf
Cooper, Rachel
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Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Ward, Kate A.
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Durdin, Ruth, Pearse, Camille, Kuh, Diana, Cooper, Rachel, Dennison, Elaine M., Cooper, Cyrus and Ward, Kate A.
(2025)
Associations of markers of inflammatory dtatus and adiposity with bone phenotype at age 60-64 years: findings from the MRC National Survey of Health and Development.
Calcified Tissue International, 116 (1), [71].
(doi:10.1007/s00223-025-01380-y).
Abstract
This study investigated associations between markers of inflammatory status and adiposity (interleukin-6 [IL-6], adiponectin and leptin) and measures of bone phenotype and fractures. The Medical Research Council (MRC) National Survey of Health and Development (NSHD) is a British birth cohort study. Participants (born during the same week in 1946) with complete data on DXA and pQCT parameters, markers of inflammatory status and adiposity, and potential confounders (498 men and 474 women) were included in cross-sectional analyses. At age 60–64 years, bone phenotype was assessed by DXA and pQCT. Fractures were self-reported at ages 60–64 and 68–70 years. Multiple linear regression was used to determine associations of IL-6, adiponectin and leptin with bone phenotype (adjusted for fat and lean mass and lifestyle confounders). Standard deviation (SD) differences in outcomes per SD increases in exposures were estimated. Higher IL-6 levels were associated with lower total volumetric bone mineral density (vBMD) (− 0.10[− 0.19, 0.00]) in men, and higher areal BMD (aBMD) at the spine (0.12[0.03, 0.22]) and whole body (0.11[0.01, 0.20]) in women. Higher levels of adiponectin were associated with lower aBMD and trabecular vBMD. In women, higher leptin levels were associated with higher cortical vBMD (0.11[0.02, 0.20]). Higher adiponectin was associated with moderately increased odds of having a fragility fracture during adulthood in women (OR 1.16 [95% CI 0.94, 1.43, p = 0.18]). Our results highlight non-mechanical associations between markers of inflammatory status and adiposity with BMD and, in women, fractures. Ensuring inflammaging is minimised may be important in healthy bone ageing.
Text
CTIN-D-25-00083 R1 17-04-25
- Accepted Manuscript
Text
s00223-025-01380-y
- Version of Record
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Accepted/In Press date: 20 April 2025
Published date: 6 May 2025
Keywords:
Dual energy X-ray absorptiometry, Peripheral quantitative computed tomography, Ageing, Bone mineral density, Inflammation, Body composition
Identifiers
Local EPrints ID: 501703
URI: http://eprints.soton.ac.uk/id/eprint/501703
ISSN: 0171-967X
PURE UUID: 6eb9dd68-78b0-43b7-9dfe-8cee647f4cd0
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Date deposited: 06 Jun 2025 16:40
Last modified: 06 Sep 2025 01:49
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Author:
Ruth Durdin
Author:
Camille Pearse
Author:
Diana Kuh
Author:
Rachel Cooper
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