Unraveling varying spatiotemporal patterns of Dengue Fever and associated exposure-response relationships with environmental variables in three Southeast Asian countries before and during COVID-19

Abstract

The enforcement of COVID-19 interventions by diverse governmental bodies, coupled with the indirect impact of COVID-19 on short-term environmental changes (e.g., plant shutdowns lead to lower greenhouse gas emissions), influences the Dengue Fever (DF) vector. This provides a unique opportunity to investigate the indirect impact of COVID-19 on DF transmission and generate insights for targeted prevention measures. We aim to compare DF transmission patterns and the exposure-response relationship of environmental variables and DF incidence in the pre- and during-COVID-19 to identify variations and assess the indirect impact of COVID-19 on DF transmission. We initially visualized the overall trend of DF transmission from 2017-2022, then conducted two quantitative analyses to compare DF transmission pre-COVID-19 (2017-2019) and during-COVID-19 (2020-2022). These analyses included time series analysis to assess DF seasonality, and a Distributed Lag Non-linear Model (DLNM) to quantify the exposure-response relationship between environmental variables and DF incidence. We observed a notable surge in Singapore during-COVID-19, particularly from May to August in 2020 and 2022, with cases multiplying several times compared to pre-COVID-19. All subregions in Thailand exhibited remarkable synchrony with a similar annual trend except 2021. Cyclic patterns remained generally consistent, but seasonal variability in Singapore has become increasingly pronounced. Monthly DF incidence in three countries varied significantly. Exposure-response relationships of DF and environmental variables show varying degrees of change, notably in Northern Thailand, where the peak relative risk for the maximum temperature-DF relationship rose from about 3-17, and the max RR of overall cumulative association 0-3 months of relative humidity increased from around 4-40. Our study is the first to compare DF transmission patterns and their relationship with environmental variables before and during COVID-19, demonstrating that the pandemic has affected DF transmission and altered the exposure-response relationship at both national and regional levels.

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ORCID for Shengjie Lai: orcid.org/0000-0001-9781-8148

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