Validity and cardio-metabolic risk profiles of DNA methylation clocks among adults in south-central Côte d’Ivoire
Validity and cardio-metabolic risk profiles of DNA methylation clocks among adults in south-central Côte d’Ivoire
Aging populations in Africa face a growing burden of non-communicable diseases (NCDs), contextualized in broad external exposome and weak health systems. These could accelerate aging and shorten lifespan. DNA methylation (DNAm) epigenetic clocks allow investigation of biological aging, and perform well in high-income countries. However, their validity has rarely been tested in low- and middle-income countries. We investigated the performance of epigenetic clocks (as aging biomarkers), and their cardio-metabolic risk profiles among adults in south-central Côte d’Ivoire.
Sanchez, Dafne
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Jeong, Ayoung
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Essé, Clemence
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Bassa, Fidèle K.
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Koné, Siaka
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Acka, Félix
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Laubhouet-Koffi, Véronique
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Kouassi, Dinard
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Utzinger, Jürg
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N’Goran, Eliézer K.
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Bonfoh, Bassirou
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Imboden, Medea
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Holloway, John W.
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Eze, Ikenna C.
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14 April 2022
Sanchez, Dafne
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Jeong, Ayoung
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Essé, Clemence
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Bassa, Fidèle K.
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Koné, Siaka
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Acka, Félix
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Laubhouet-Koffi, Véronique
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Kouassi, Dinard
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Utzinger, Jürg
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N’Goran, Eliézer K.
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Bonfoh, Bassirou
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Imboden, Medea
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Holloway, John W.
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Eze, Ikenna C.
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Sanchez, Dafne, Jeong, Ayoung, Essé, Clemence, Bassa, Fidèle K., Koné, Siaka, Acka, Félix, Laubhouet-Koffi, Véronique, Kouassi, Dinard, Utzinger, Jürg, N’Goran, Eliézer K., Bonfoh, Bassirou, Imboden, Medea, Holloway, John W. and Eze, Ikenna C.
(2022)
Validity and cardio-metabolic risk profiles of DNA methylation clocks among adults in south-central Côte d’Ivoire.
Epigenetics Communications, 2, [1].
(doi:10.1186/s43682-022-00008-8).
Abstract
Aging populations in Africa face a growing burden of non-communicable diseases (NCDs), contextualized in broad external exposome and weak health systems. These could accelerate aging and shorten lifespan. DNA methylation (DNAm) epigenetic clocks allow investigation of biological aging, and perform well in high-income countries. However, their validity has rarely been tested in low- and middle-income countries. We investigated the performance of epigenetic clocks (as aging biomarkers), and their cardio-metabolic risk profiles among adults in south-central Côte d’Ivoire.
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s43682-022-00008-8
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Accepted/In Press date: 31 March 2022
Published date: 14 April 2022
Identifiers
Local EPrints ID: 501996
URI: http://eprints.soton.ac.uk/id/eprint/501996
ISSN: 2730-7034
PURE UUID: e8c95e25-16d4-4531-9a20-66d8afc3a4f5
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Date deposited: 13 Jun 2025 16:30
Last modified: 22 Aug 2025 01:42
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Contributors
Author:
Dafne Sanchez
Author:
Ayoung Jeong
Author:
Clemence Essé
Author:
Fidèle K. Bassa
Author:
Siaka Koné
Author:
Félix Acka
Author:
Véronique Laubhouet-Koffi
Author:
Dinard Kouassi
Author:
Jürg Utzinger
Author:
Eliézer K. N’Goran
Author:
Bassirou Bonfoh
Author:
Medea Imboden
Author:
Ikenna C. Eze
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