READ ME File For 'Dataset title'

Dataset DOI: 10.5258/SOTON/D3476

ReadMe Author: Anushma Sharma, University of Southampton ORCID ID 0009-0007-7266-9837

This dataset supports the thesis entitled "Chronological evaluation of functional changes in neonatal skin: A temporal evaluation of skin maturation" 
AWARDED BY: University of Southampton
DATE OF AWARD: 2025


Date of data collection: 2017-2018

Geographic location of data collection: Princess Anne Hospital, University Hospitals Southampton

Licence: CC-BY

Related projects/Funders: Paediatric research theme-National Institute for Healthcare Research

--------------------
DATA & FILE OVERVIEW
--------------------

This dataset contains:

Excel file of annonymised data related to structure and function of neonatal skin

File originally created on 23.11.2021

--------------------------
METHODOLOGICAL INFORMATION
--------------------------

Description of methods used for collection/generation of data: Cohort study exploring the chronological changes in neonatal skin.
All infants born in PAH over the course of the study were eligible for inclusion except those (a) with dermatological conditions (e.g., collodion skin, harlequin baby), (b) receiving therapeutic hypothermia or (c) with medical condition prohibiting skin data collection

TEWL(transepidermal water loss) measurements were made using widely validated open-chamber system (Tewameter®TM 300, Courage+khazaka Electronic, Cologne, Germany)

High frequency ultrasound images of the skin, including epidermal and dermal layers were recorded using a portable scanner specifically developed to examine the skin and underlying soft tissue (EPISCAN I-200. Longport, Inc., Glen Mills, PA). Measurements are made with high frequency probe (35 MHz) to obtain better resolution in the first 15mm of soft tissue.

Further details on the sampling methodology and protocols followed are described in chapter 3 of Sharma, Anushma (2025) Chronological evaluation of functional changes in neonatal skin: A temporal evaluation of skin maturation. University of Southampton, Doctoral Thesis, 201pp. 

People involved with sample collection, processing, analysis and/or submission: Anushma Sharma, Peter Worsley, Eugene Healy, Howard Clark

--------------------------
DATA-SPECIFIC INFORMATION 
--------------------------

Number of variables: 10

Number of cases/rows: 59

Variable list, defining any abbreviations, units of measure, codes or symbols used: TEWL (transepidermal water loss), US (Ultrasound)
   
Missing data codes: nil

Specialized formats or other abbreviations used:nil


--------------------------
ReadMe created: June 2025