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Data from 'Mapping the b-Catenin interactome' thesis

Data from 'Mapping the b-Catenin interactome' thesis
Data from 'Mapping the b-Catenin interactome' thesis
This dataset supports the thesis entitled: Mapping the b-Catenin Interactome: CRISPR-Based Functional Proteomics, Proximity Labelling, and Small Molecule Screening for Wnt-Targeted Cancer Therapy. MiniTurbo_SAINT_DATASET.zip contains the results obtained from inputting the un-anlaysed processed Mass Spec data from testing MiniTurbo technology in U2OS cells into the SAINT software and the results from Gene ontology analysis. Pathway, GO molecular function, GO cellular component, GO Biological Process were all analysed and proteins which had P<0.05 were selected as significant for analysis. MiniTurbo_Database_comparison_.zip contains comparisons between databases BIOGrid and INTACT and novel data from MiniTurbo-Affinity based purification Mass spectrometry looking at direct interactors of BAIT protein B-catenin. For more information see the readme files in each zipped file.
University of Southampton
John, Steve Shaju
b5ffef11-a31e-4013-9bba-f492eb8b93c2
John, Steve Shaju
b5ffef11-a31e-4013-9bba-f492eb8b93c2

John, Steve Shaju (2025) Data from 'Mapping the b-Catenin interactome' thesis. University of Southampton doi:10.5258/SOTON/D3559 [Dataset]

Record type: Dataset

Abstract

This dataset supports the thesis entitled: Mapping the b-Catenin Interactome: CRISPR-Based Functional Proteomics, Proximity Labelling, and Small Molecule Screening for Wnt-Targeted Cancer Therapy. MiniTurbo_SAINT_DATASET.zip contains the results obtained from inputting the un-anlaysed processed Mass Spec data from testing MiniTurbo technology in U2OS cells into the SAINT software and the results from Gene ontology analysis. Pathway, GO molecular function, GO cellular component, GO Biological Process were all analysed and proteins which had P<0.05 were selected as significant for analysis. MiniTurbo_Database_comparison_.zip contains comparisons between databases BIOGrid and INTACT and novel data from MiniTurbo-Affinity based purification Mass spectrometry looking at direct interactors of BAIT protein B-catenin. For more information see the readme files in each zipped file.

Archive
MiniTurbo_SAINT_DATASET.zip - Dataset
Available under License Creative Commons Attribution.
Download (779kB)
Archive
MiniTurbo_Database_comparison_.zip - Dataset
Available under License Creative Commons Attribution.
Download (815kB)

More information

Published date: 2025
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Identifiers

Local EPrints ID: 502134
URI: http://eprints.soton.ac.uk/id/eprint/502134
DOI: doi:10.5258/SOTON/D3559
PURE UUID: 644ef499-3aae-4068-9cd0-000339eef465
ORCID for Steve Shaju John: ORCID iD orcid.org/0009-0005-9463-2491

Catalogue record

Date deposited: 17 Jun 2025 16:42
Last modified: 18 Jun 2025 02:00

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Contributors

Creator: Steve Shaju John ORCID iD

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