Free Radicals in Inflammation
Free Radicals in Inflammation
This chapter sheds some light on the enigmatic world of "free radicals" as it relates to human physiology and disease, with particular emphasis on inflammation. Inflammatory processes are generally associated with changes in cellular status toward a more oxidized redox tone compared to a normal cell, a situation characterized by an increased production of reactive oxygen species (ROS) and accompanying "oxidative stress". With the increasing knowledge of free radical species interactions, it has become increasingly clear that ROS, reactive nitrogen species (RNS), and reactive sulfur species (RSS) have broad signaling effects well beyond individual cells. The chapter briefly reviews the properties of some important classes and key representatives and look at their role in the intricate network of regulatory processes that fuel the cellular machinery, allowing cells and tissues/organs to quickly adapt to changes in environmental conditions, energetic and metabolic demand, and nutritional status.
free radical production, inflammation, innate immune response, oxidative stress, reactive nitrogen species, reactive oxygen species, reactive sulfur species, redox code, redox regulation
695-726
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Cumpstey, Andrew
cd040417-5e62-41d2-8640-1ec8905858a7
11 December 2017
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Cumpstey, Andrew
cd040417-5e62-41d2-8640-1ec8905858a7
Feelisch, Martin and Cumpstey, Andrew
(2017)
Free Radicals in Inflammation.
In,
Cavaillon, Jean-Marc and Singer, Mervyn
(eds.)
Inflammation: from Molecular and Cellular Mechanisms to the Clinic.
Wiley, .
(doi:10.1002/9783527692156.ch27).
Record type:
Book Section
Abstract
This chapter sheds some light on the enigmatic world of "free radicals" as it relates to human physiology and disease, with particular emphasis on inflammation. Inflammatory processes are generally associated with changes in cellular status toward a more oxidized redox tone compared to a normal cell, a situation characterized by an increased production of reactive oxygen species (ROS) and accompanying "oxidative stress". With the increasing knowledge of free radical species interactions, it has become increasingly clear that ROS, reactive nitrogen species (RNS), and reactive sulfur species (RSS) have broad signaling effects well beyond individual cells. The chapter briefly reviews the properties of some important classes and key representatives and look at their role in the intricate network of regulatory processes that fuel the cellular machinery, allowing cells and tissues/organs to quickly adapt to changes in environmental conditions, energetic and metabolic demand, and nutritional status.
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More information
e-pub ahead of print date: 31 October 2017
Published date: 11 December 2017
Keywords:
free radical production, inflammation, innate immune response, oxidative stress, reactive nitrogen species, reactive oxygen species, reactive sulfur species, redox code, redox regulation
Identifiers
Local EPrints ID: 502266
URI: http://eprints.soton.ac.uk/id/eprint/502266
PURE UUID: fc020627-4c10-455f-bb07-57cf3a05c46a
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Date deposited: 19 Jun 2025 16:56
Last modified: 24 Sep 2025 02:09
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Contributors
Author:
Andrew Cumpstey
Editor:
Jean-Marc Cavaillon
Editor:
Mervyn Singer
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