A floating 3D printed formulation for the coadministration and sustained release of antihypertensive drugs - Underlying CT data

Katsamenis, Orestis L., Fatouros, Dimitrios G. and Gioumouxouzis, Christos I. (2024) A floating 3D printed formulation for the coadministration and sustained release of antihypertensive drugs - Underlying CT data. Zenodo doi:10.5281/zenodo.10614260 [Dataset]

Abstract

Underlying CT data of Zgouro et al (2024) "A floating 3D printed polypill formulation for the coadministration and sustained release of antihypertensive drugs", International Journal of Pharmaceutics, 655, 124058, https://doi.org/10.1016/j.ijpharm.2024.124058 Microfocus Computed Tomography (μCT) X-ray microfocus computed tomography (μCT) was employed for the characterization of the microstructure of the printed object, assessing the overall volume, porosity, local thickness and other printing defects. The imaging took place at the University of Southampton’s μ-VIS X-ray Imaging Centre (www.muvis.org) / 3D X-ray Histology facility using a customized μCT scanner optimized for 3D X-ray histology (www.xrayhistology.org) (Katsamenis et al., 2023) based on Nikon’s XTH225ST system (Nikon Metrology, Castle Donington, UK). The scanner was operated at 110 kVp / 90 μA (9.9 W), with the X-ray beam prefiltered using 0.04 mm of aluminum. The source-to-object and source-to-detector distances were 28.4 mm and 1136.7 mm, respectively, resulting in a magnification factor of 40x. Acquisition parameters included 2201 projections, averaging 4 frames per projection, with an exposure time of 177 ms per projection. The 2850 x 2850 dexels detector was binned 2x (virtual detector: 1425 × 1425 dexels), resulting in an isotropic voxel edge of 7.5 μm. The reconstructed data underwent visualization and analysis using Dragonfly software (Comet Technologies Canada Inc.; software available at http://www.theobjects.com/dragonfly).

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Contributors

Creator: Orestis L. Katsamenis

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