James, Thomas J., Mayes, Harry, Alnajjar, Mohammad, Newell, Yasmin, Kohlert, Eliska, Shute, Janis, Perissiou, Maria, Corbett, Jo, Costello, Joseph T., Neupert, Emma, Moore, Joseph M., Morgan, Paul T., Simms, Chris, Saynor, Zoe L. and Shepherd, Anthony I. (2025) The effect of intact vs hydrolysed collagen on recovery from exercise induced muscle damage: a double-blind, randomised, placebo-controlled trial. Journal of Nutritional Physiology, 1. (doi:10.1016/j.jnphys.2025.100003).
Abstract
Collagen supplementation has the potential to aid in the recovery from exercise-induced muscle damage (EIMD). A novel collagen supplement, rich in intact type I collagen (Natiiv™, Trinsic Collagen Limited), potentially increases delivery of its constituent amino acids and intact alpha helices to the extracellular matrix (ECM) for remodelling. Thirty-six healthy, young and active adults (M = 27, age: 21.3 ± 4.3 years, body mass index; 25.2 ± 5.7 kg m−2) were assigned (1:1:1) in a double-blind, randomised, placebo-controlled trial, to consume either: Natiiv™ collagen (0.255 g·day−1 of Natiiv™ collagen), hydrolysed collagen (20 g·day−1 of collagen; Peptan®, Rousselot, Belgium), or placebo (collagen depleted alkaline water; Natiiv™), for 30-days. On day-28, muscle damage-inducing exercise (150 drop jumps) was undertaken. Exercise performance (counter movement, squat, and drop jumps), quadriceps strength (maximal voluntary isometric contraction; leg pain (visual analogue scale, pain pressure threshold, short recovery and stress scale questionnaire); and knee inflammation (via colour fraction ultrasonography) and systemic inflammation (IL-6, IL-10, TNFα); ECM damage (hydroxyproline) and; bone turnover (β-CTX and P1NP) were assessed at baseline, 2.5-h, 24-h, 48-h and 72-h following EIMD. Thirty days of Natiiv™ collagen supplementation had no significant effect on any outcome measure (P > 0.05 with small-medium effect sizes) compared to hydrolysed collagen or placebo. Future studies should explore the potential efficacy of Natiiv™ collagen supplementation in other relevant populations/scenarios and assess the post-prandial bioavailability of Natiiv™ collagen and, if impaired, explore interventions that can increase its bioavailability and optimise recovery from EIMD.
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