Endogenous circadian rhythms in mood and well-being
Endogenous circadian rhythms in mood and well-being
Objectives: we examined whether the endogenous circadian timing system modulates proxies of mood vulnerability and well-being.
Methods: nineteen healthy participants (mean age: 26.6 years [23.0-30.2], seven females, body-mass index: 22.8 kg/m2 [21.1-25]) completed a laboratory protocol with a 32-hour Constant Routine, a stringently controlled protocol designed to isolate assessment of endogenous circadian rhythms. We assessed hourly anxiety- and depression-like mood (i.e., those typically observed in depression and anxiety) and well-being (i.e., associated with mental fatigue and physical comfort).
Results: significant endogenous circadian rhythms were observed in anxiety-like and depression-like mood, as well as well-being (p values from the mixed-model analysis using false discovery rates < .001). Post-hoc comparisons revealed more anxiety-like and depression-like mood during the circadian phase 60°-75° (∼8–9 a.m.), and more mental fatigue and less physical comfort during the circadian phase 30°-60° (∼6–8 a.m.).
Conclusions: our data indicate endogenous circadian rhythms in anxiety-like and depression-like mood and well-being in healthy young adults. Future studies will help establish circadian-based therapeutics for individuals experiencing mood and anxiety disorders.
S149-S153
Scheer, Frank A.J.L.
91fea554-bacb-4008-ae58-8fd2bbc5d0fe
Chellappa, Sarah L.
516582b5-3cba-4644-86c9-14c91a4510f2
16 April 2024
Scheer, Frank A.J.L.
91fea554-bacb-4008-ae58-8fd2bbc5d0fe
Chellappa, Sarah L.
516582b5-3cba-4644-86c9-14c91a4510f2
Scheer, Frank A.J.L. and Chellappa, Sarah L.
(2024)
Endogenous circadian rhythms in mood and well-being.
Sleep Health, 10 (1), .
(doi:10.1016/j.sleh.2023.07.012).
Abstract
Objectives: we examined whether the endogenous circadian timing system modulates proxies of mood vulnerability and well-being.
Methods: nineteen healthy participants (mean age: 26.6 years [23.0-30.2], seven females, body-mass index: 22.8 kg/m2 [21.1-25]) completed a laboratory protocol with a 32-hour Constant Routine, a stringently controlled protocol designed to isolate assessment of endogenous circadian rhythms. We assessed hourly anxiety- and depression-like mood (i.e., those typically observed in depression and anxiety) and well-being (i.e., associated with mental fatigue and physical comfort).
Results: significant endogenous circadian rhythms were observed in anxiety-like and depression-like mood, as well as well-being (p values from the mixed-model analysis using false discovery rates < .001). Post-hoc comparisons revealed more anxiety-like and depression-like mood during the circadian phase 60°-75° (∼8–9 a.m.), and more mental fatigue and less physical comfort during the circadian phase 30°-60° (∼6–8 a.m.).
Conclusions: our data indicate endogenous circadian rhythms in anxiety-like and depression-like mood and well-being in healthy young adults. Future studies will help establish circadian-based therapeutics for individuals experiencing mood and anxiety disorders.
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Accepted/In Press date: 21 July 2023
e-pub ahead of print date: 28 August 2023
Published date: 16 April 2024
Identifiers
Local EPrints ID: 502839
URI: http://eprints.soton.ac.uk/id/eprint/502839
ISSN: 2352-7218
PURE UUID: 97b13281-3b97-4db9-b485-f7af9deeb20d
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Date deposited: 09 Jul 2025 16:36
Last modified: 22 Aug 2025 02:39
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Author:
Frank A.J.L. Scheer
Author:
Sarah L. Chellappa
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