Trait impulsivity predicts treatment response in gambling disorder

Chamberlain, Samuel R., Ioannidis, Konstantinos and Grant, Jon E. (2025) Trait impulsivity predicts treatment response in gambling disorder. Clinical Neuropharmacology, 48 (2), 27-28. (doi:10.1097/WNF.0000000000000622).

Record type: Article

Abstract

Objectives: impulsivity is thought to be a core feature of gambling disorder, yet little is known as to whether trait impulsivity predicts treatment response. Methods: Data were pooled from 2 previous randomized controlled pharmacological trials using naltrexone and N-acetyl cysteine.

Results: trait impulsivity statistically explained variation in medication treatment response (P = 0.0260, R2 = 0.26). Higher baseline motor impulsiveness was associated with greater treatment response (P = 0.009).

Conclusions: measures of impulsivity may thus be important to include in future large-scale datasets, in trial settings but also routine clinical gambling clinic practice, toward building predictive algorithms that may ultimately help to inform optimal treatment choices and improve outcomes.

Text

impulsivity_and_treatment_gambling-10-16-24 - Accepted Manuscript

Restricted to Repository staff only until 1 March 2026.

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