Plasma lipid concentrations in children with cystic fibrosis: the value of a high-fat diet and pancreatic supplementation
Plasma lipid concentrations in children with cystic fibrosis: the value of a high-fat diet and pancreatic supplementation
Impaired digestion of dietary fat is an almost universal feature of cystic fibrosis (CF) which results in low concentrations of essential fatty acids in plasma lipids. We have evaluated the effect of a high-lipid diet and pancreatic enzyme supplementation, using enteric-coated microsphere preparations, on plasma lipid concentrations in paediatric CF patients. Absorption of dietary lipid was comparable between control and CF subjects. This resulted in plasma cholesterol, triacylglycerol, total phosphatidylcholine and individual phosphatidylcholine molecular species concentrations in CF patients which were in the same range as those in controls. Normal values for these variables were also found in patients with clinically detectable liver disease. These results show that present dietary management of CF patients supports normal plasma lipid concentrations.
Childhood, Cystic fibrosis, Plasma lipids, Plasma phospholipids
959-964
Burdge, Graham C.
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Goodale, Alissa J.
425d9cf1-8314-431c-8ade-b4c0c14a744c
Hill, Catherine Mary
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Halford, Penny J.
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Lambert, Elizabeth J.
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Postle, Anthony D.
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Rolles, Christopher J.
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1 June 1994
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Goodale, Alissa J.
425d9cf1-8314-431c-8ade-b4c0c14a744c
Hill, Catherine Mary
5460b286-fbef-4f0e-81a8-2a64be4c51c2
Halford, Penny J.
0a63763c-8466-4d7f-9bfb-be4ac7b9166c
Lambert, Elizabeth J.
9caa0ab4-2cbd-4452-ab2c-7587b8cebd07
Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Rolles, Christopher J.
daaa2be1-01b1-4aa7-8bec-397b4b463a2f
Burdge, Graham C., Goodale, Alissa J., Hill, Catherine Mary, Halford, Penny J., Lambert, Elizabeth J., Postle, Anthony D. and Rolles, Christopher J.
(1994)
Plasma lipid concentrations in children with cystic fibrosis: the value of a high-fat diet and pancreatic supplementation.
British Journal of Nutrition, 71 (6), .
(doi:10.1079/BJN19940199).
Abstract
Impaired digestion of dietary fat is an almost universal feature of cystic fibrosis (CF) which results in low concentrations of essential fatty acids in plasma lipids. We have evaluated the effect of a high-lipid diet and pancreatic enzyme supplementation, using enteric-coated microsphere preparations, on plasma lipid concentrations in paediatric CF patients. Absorption of dietary lipid was comparable between control and CF subjects. This resulted in plasma cholesterol, triacylglycerol, total phosphatidylcholine and individual phosphatidylcholine molecular species concentrations in CF patients which were in the same range as those in controls. Normal values for these variables were also found in patients with clinically detectable liver disease. These results show that present dietary management of CF patients supports normal plasma lipid concentrations.
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Published date: 1 June 1994
Keywords:
Childhood, Cystic fibrosis, Plasma lipids, Plasma phospholipids
Identifiers
Local EPrints ID: 503183
URI: http://eprints.soton.ac.uk/id/eprint/503183
ISSN: 0007-1145
PURE UUID: 5c3a986f-f317-4fc1-aad2-bab67de8c081
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Date deposited: 23 Jul 2025 16:39
Last modified: 24 Jul 2025 01:32
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Author:
Alissa J. Goodale
Author:
Catherine Mary Hill
Author:
Penny J. Halford
Author:
Elizabeth J. Lambert
Author:
Christopher J. Rolles
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