Medication-invariant resting aperiodic and periodic neural activity in Parkinson's disease
Medication-invariant resting aperiodic and periodic neural activity in Parkinson's disease
Parkinson's disease (PD) has been associated with greater total power in canonical frequency bands (i.e., alpha, beta) of the resting electroencephalogram (EEG). However, PD has also been associated with a reduction in the proportion of total power across all frequency bands. This discrepancy may be explained by aperiodic activity (exponent and offset) present across all frequency bands. Here, we examined differences in the eyes-open (EO) and eyes-closed (EC) resting EEG of PD participants (N = 26) on and off medication, and age-matched healthy controls (CTL; N = 26). We extracted power from canonical frequency bands using traditional methods (total alpha and beta power) and extracted separate parameters for periodic (parameterized alpha and beta power) and aperiodic activity (exponent and offset). Cluster-based permutation tests over spatial and frequency dimensions indicated that total alpha and beta power, and aperiodic exponent and offset were greater in PD participants, independent of medication status. After removing the exponent and offset, greater alpha power in PD (vs. CTL) was only present in EO recordings and no reliable differences in beta power were observed. Differences between PD and CTL in the resting EEG are likely driven by aperiodic activity, suggestive of greater relative inhibitory neural activity and greater neuronal spiking. Our findings suggest that resting EEG activity in PD is characterized by medication-invariant differences in aperiodic activity which is independent of the increase in alpha power with EO. This highlights the importance of considering aperiodic activity contributions to the neural correlates of brain disorders.
aperiodic activity, cluster-based permutation tests, EEG, excitatory and inhibitory (E:I) balance, Parkinson's disease
McKeown, Daniel J.
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Jones, Manon
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Pihl, Camilla
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Finley, Anna J.
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Kelley, Nicholas
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Baumann, Oliver
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Schinazi, Victor R.
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Moustafa, Ahmed A.
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Cavanagh, James F.
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Angus, Douglas J.
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13 November 2024
McKeown, Daniel J.
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Jones, Manon
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Pihl, Camilla
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Finley, Anna J.
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Kelley, Nicholas
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Baumann, Oliver
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Schinazi, Victor R.
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Moustafa, Ahmed A.
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Cavanagh, James F.
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Angus, Douglas J.
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McKeown, Daniel J., Jones, Manon, Pihl, Camilla, Finley, Anna J., Kelley, Nicholas, Baumann, Oliver, Schinazi, Victor R., Moustafa, Ahmed A., Cavanagh, James F. and Angus, Douglas J.
(2024)
Medication-invariant resting aperiodic and periodic neural activity in Parkinson's disease.
Psychophysiology, 61 (4), [e14478].
(doi:10.1111/psyp.14478).
Abstract
Parkinson's disease (PD) has been associated with greater total power in canonical frequency bands (i.e., alpha, beta) of the resting electroencephalogram (EEG). However, PD has also been associated with a reduction in the proportion of total power across all frequency bands. This discrepancy may be explained by aperiodic activity (exponent and offset) present across all frequency bands. Here, we examined differences in the eyes-open (EO) and eyes-closed (EC) resting EEG of PD participants (N = 26) on and off medication, and age-matched healthy controls (CTL; N = 26). We extracted power from canonical frequency bands using traditional methods (total alpha and beta power) and extracted separate parameters for periodic (parameterized alpha and beta power) and aperiodic activity (exponent and offset). Cluster-based permutation tests over spatial and frequency dimensions indicated that total alpha and beta power, and aperiodic exponent and offset were greater in PD participants, independent of medication status. After removing the exponent and offset, greater alpha power in PD (vs. CTL) was only present in EO recordings and no reliable differences in beta power were observed. Differences between PD and CTL in the resting EEG are likely driven by aperiodic activity, suggestive of greater relative inhibitory neural activity and greater neuronal spiking. Our findings suggest that resting EEG activity in PD is characterized by medication-invariant differences in aperiodic activity which is independent of the increase in alpha power with EO. This highlights the importance of considering aperiodic activity contributions to the neural correlates of brain disorders.
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Psychophysiology - 2023 - McKeown - Medication‐invariant resting aperiodic and periodic neural activity in Parkinson s
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More information
Accepted/In Press date: 16 October 2023
e-pub ahead of print date: 8 November 2023
Published date: 13 November 2024
Keywords:
aperiodic activity, cluster-based permutation tests, EEG, excitatory and inhibitory (E:I) balance, Parkinson's disease
Identifiers
Local EPrints ID: 503238
URI: http://eprints.soton.ac.uk/id/eprint/503238
ISSN: 0048-5772
PURE UUID: 1e4d9966-3727-4e7d-ac5b-5930ada7a372
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Date deposited: 24 Jul 2025 17:04
Last modified: 22 Aug 2025 02:27
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Contributors
Author:
Daniel J. McKeown
Author:
Manon Jones
Author:
Camilla Pihl
Author:
Anna J. Finley
Author:
Oliver Baumann
Author:
Victor R. Schinazi
Author:
Ahmed A. Moustafa
Author:
James F. Cavanagh
Author:
Douglas J. Angus
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