Integration of paper microfluidic sensors into contact lenses for tear fluid analysis
Integration of paper microfluidic sensors into contact lenses for tear fluid analysis
In this article, using the integration of paper microfluidics within laser-inscribed commercial contact lenses, we demonstrate the multiplexed detection of clinically relevant analytes including hydrogen ions, proteins, glucose, nitrites and l-ascorbic acid, all sampled directly from model tears. In vitro measurements involved the optimization of colorimetric assays, with readouts collected, stored and analyzed using a bespoke Tears Diagnostics smartphone application prototype. We demonstrate the potential of the device to perform discrete measurements either for medical diagnosis or disease screening in the clinic or at the point-of-care (PoC), with future applications including monitoring of ocular infections, uveitis, diabetes, keratopathies and assessing oxidative stress.
3970-3979
Moreddu, Rosalia
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Elsherif, Mohamed
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Adams, Hadie
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Moschou, Despina
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Cordeiro, Maria F.
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Wolffsohn, James S.
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Vigolo, Daniele
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Butt, Haider
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Cooper, Jonathan M.
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Yetisen, Ali K.
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7 November 2020
Moreddu, Rosalia
8a5d77bc-dac4-4966-baa3-be26c5eec1ef
Elsherif, Mohamed
7d3a17e1-6eaf-42df-ab35-ce3a97f54622
Adams, Hadie
d0b17d24-ed96-405a-99ae-fa27fa9ff6b3
Moschou, Despina
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Cordeiro, Maria F.
4b3b84fe-298c-47d6-a079-596339bd3d7f
Wolffsohn, James S.
1cf21ee7-419c-4f86-aa94-e76a10422ed1
Vigolo, Daniele
43c6b4f9-285b-47b9-8848-fa15eee7d698
Butt, Haider
4ffc26d6-273f-4684-a832-662bd055fc54
Cooper, Jonathan M.
c8f72162-161e-4187-a2a1-05ccbf03af5a
Yetisen, Ali K.
73141f83-3104-470a-bbf5-a7b42d9420a1
Moreddu, Rosalia, Elsherif, Mohamed, Adams, Hadie, Moschou, Despina, Cordeiro, Maria F., Wolffsohn, James S., Vigolo, Daniele, Butt, Haider, Cooper, Jonathan M. and Yetisen, Ali K.
(2020)
Integration of paper microfluidic sensors into contact lenses for tear fluid analysis.
Lab on a Chip, 20 (21), .
(doi:10.1039/d0lc00438c).
Abstract
In this article, using the integration of paper microfluidics within laser-inscribed commercial contact lenses, we demonstrate the multiplexed detection of clinically relevant analytes including hydrogen ions, proteins, glucose, nitrites and l-ascorbic acid, all sampled directly from model tears. In vitro measurements involved the optimization of colorimetric assays, with readouts collected, stored and analyzed using a bespoke Tears Diagnostics smartphone application prototype. We demonstrate the potential of the device to perform discrete measurements either for medical diagnosis or disease screening in the clinic or at the point-of-care (PoC), with future applications including monitoring of ocular infections, uveitis, diabetes, keratopathies and assessing oxidative stress.
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Published date: 7 November 2020
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© The Royal Society of Chemistry.
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Local EPrints ID: 503366
URI: http://eprints.soton.ac.uk/id/eprint/503366
ISSN: 1473-0197
PURE UUID: de72a0ac-0a2c-4617-8c12-e977184401d5
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Date deposited: 29 Jul 2025 17:04
Last modified: 30 Jul 2025 02:14
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Contributors
Author:
Rosalia Moreddu
Author:
Mohamed Elsherif
Author:
Hadie Adams
Author:
Despina Moschou
Author:
Maria F. Cordeiro
Author:
James S. Wolffsohn
Author:
Daniele Vigolo
Author:
Haider Butt
Author:
Jonathan M. Cooper
Author:
Ali K. Yetisen
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