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Integration of paper microfluidic sensors into contact lenses for tear fluid analysis

Integration of paper microfluidic sensors into contact lenses for tear fluid analysis
Integration of paper microfluidic sensors into contact lenses for tear fluid analysis

In this article, using the integration of paper microfluidics within laser-inscribed commercial contact lenses, we demonstrate the multiplexed detection of clinically relevant analytes including hydrogen ions, proteins, glucose, nitrites and l-ascorbic acid, all sampled directly from model tears. In vitro measurements involved the optimization of colorimetric assays, with readouts collected, stored and analyzed using a bespoke Tears Diagnostics smartphone application prototype. We demonstrate the potential of the device to perform discrete measurements either for medical diagnosis or disease screening in the clinic or at the point-of-care (PoC), with future applications including monitoring of ocular infections, uveitis, diabetes, keratopathies and assessing oxidative stress.

1473-0197
3970-3979
Moreddu, Rosalia
8a5d77bc-dac4-4966-baa3-be26c5eec1ef
Elsherif, Mohamed
7d3a17e1-6eaf-42df-ab35-ce3a97f54622
Adams, Hadie
d0b17d24-ed96-405a-99ae-fa27fa9ff6b3
Moschou, Despina
b5fef8ae-e4cb-4de5-8ade-1b5c807c74d3
Cordeiro, Maria F.
4b3b84fe-298c-47d6-a079-596339bd3d7f
Wolffsohn, James S.
1cf21ee7-419c-4f86-aa94-e76a10422ed1
Vigolo, Daniele
43c6b4f9-285b-47b9-8848-fa15eee7d698
Butt, Haider
4ffc26d6-273f-4684-a832-662bd055fc54
Cooper, Jonathan M.
c8f72162-161e-4187-a2a1-05ccbf03af5a
Yetisen, Ali K.
73141f83-3104-470a-bbf5-a7b42d9420a1
Moreddu, Rosalia
8a5d77bc-dac4-4966-baa3-be26c5eec1ef
Elsherif, Mohamed
7d3a17e1-6eaf-42df-ab35-ce3a97f54622
Adams, Hadie
d0b17d24-ed96-405a-99ae-fa27fa9ff6b3
Moschou, Despina
b5fef8ae-e4cb-4de5-8ade-1b5c807c74d3
Cordeiro, Maria F.
4b3b84fe-298c-47d6-a079-596339bd3d7f
Wolffsohn, James S.
1cf21ee7-419c-4f86-aa94-e76a10422ed1
Vigolo, Daniele
43c6b4f9-285b-47b9-8848-fa15eee7d698
Butt, Haider
4ffc26d6-273f-4684-a832-662bd055fc54
Cooper, Jonathan M.
c8f72162-161e-4187-a2a1-05ccbf03af5a
Yetisen, Ali K.
73141f83-3104-470a-bbf5-a7b42d9420a1

Moreddu, Rosalia, Elsherif, Mohamed, Adams, Hadie, Moschou, Despina, Cordeiro, Maria F., Wolffsohn, James S., Vigolo, Daniele, Butt, Haider, Cooper, Jonathan M. and Yetisen, Ali K. (2020) Integration of paper microfluidic sensors into contact lenses for tear fluid analysis. Lab on a Chip, 20 (21), 3970-3979. (doi:10.1039/d0lc00438c).

Record type: Article

Abstract

In this article, using the integration of paper microfluidics within laser-inscribed commercial contact lenses, we demonstrate the multiplexed detection of clinically relevant analytes including hydrogen ions, proteins, glucose, nitrites and l-ascorbic acid, all sampled directly from model tears. In vitro measurements involved the optimization of colorimetric assays, with readouts collected, stored and analyzed using a bespoke Tears Diagnostics smartphone application prototype. We demonstrate the potential of the device to perform discrete measurements either for medical diagnosis or disease screening in the clinic or at the point-of-care (PoC), with future applications including monitoring of ocular infections, uveitis, diabetes, keratopathies and assessing oxidative stress.

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More information

Published date: 7 November 2020
Additional Information: Publisher Copyright: © The Royal Society of Chemistry.

Identifiers

Local EPrints ID: 503366
URI: http://eprints.soton.ac.uk/id/eprint/503366
ISSN: 1473-0197
PURE UUID: de72a0ac-0a2c-4617-8c12-e977184401d5
ORCID for Rosalia Moreddu: ORCID iD orcid.org/0000-0002-0332-1606

Catalogue record

Date deposited: 29 Jul 2025 17:04
Last modified: 30 Jul 2025 02:14

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Contributors

Author: Rosalia Moreddu ORCID iD
Author: Mohamed Elsherif
Author: Hadie Adams
Author: Despina Moschou
Author: Maria F. Cordeiro
Author: James S. Wolffsohn
Author: Daniele Vigolo
Author: Haider Butt
Author: Jonathan M. Cooper
Author: Ali K. Yetisen

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