Stretchable nanostructures as optomechanical strain sensors for ophthalmic applications
Stretchable nanostructures as optomechanical strain sensors for ophthalmic applications
The intraocular pressure (IOP) is a physiological parameter that plays a crucial role in preventing, diagnosing, and treating ocular diseases. For example, lowering the IOP is the primary focus of glaucoma management. However, IOP is a widely varying parameter, and one-off measurements are prompt to errors. Developing portable solutions for continuous monitoring the IOP is a critical goal in ophthalmology. Here, stretchable nanostructures were developed as strain-tunable diffraction gratings and integrated into a contact lens. They exhibited a limit of detection (LOD) <2 mmHg and a linear response in the range of interest (15-35 mmHg). Nanopatterns were characterized under monochromatic laser sources and further integrated into a soft contact lens. A smartphone readout method based on preferentially reflected colors was proposed to pave the way toward smartphone-based ocular health monitoring.
contact lenses, diffraction gratings, glaucoma, intraocular pressure (IOP), nanopillars
5416-5424
Moreddu, Rosalia
8a5d77bc-dac4-4966-baa3-be26c5eec1ef
Mahmoodi, Nasim
18f7a7ec-f638-4a11-9606-a38e14526058
Kassanos, Panagiotis
a4f92572-eea7-4149-8fb1-453dd83cd058
Vigolo, Daniele
43c6b4f9-285b-47b9-8848-fa15eee7d698
Mendes, Paula M.
2e7ca2ec-b6d8-41c4-814b-0a8a08608b5d
Yetisen, Ali K.
73141f83-3104-470a-bbf5-a7b42d9420a1
12 November 2021
Moreddu, Rosalia
8a5d77bc-dac4-4966-baa3-be26c5eec1ef
Mahmoodi, Nasim
18f7a7ec-f638-4a11-9606-a38e14526058
Kassanos, Panagiotis
a4f92572-eea7-4149-8fb1-453dd83cd058
Vigolo, Daniele
43c6b4f9-285b-47b9-8848-fa15eee7d698
Mendes, Paula M.
2e7ca2ec-b6d8-41c4-814b-0a8a08608b5d
Yetisen, Ali K.
73141f83-3104-470a-bbf5-a7b42d9420a1
Moreddu, Rosalia, Mahmoodi, Nasim, Kassanos, Panagiotis, Vigolo, Daniele, Mendes, Paula M. and Yetisen, Ali K.
(2021)
Stretchable nanostructures as optomechanical strain sensors for ophthalmic applications.
ACS Applied Polymer Materials, 3 (11), .
(doi:10.1021/acsapm.1c00703).
Abstract
The intraocular pressure (IOP) is a physiological parameter that plays a crucial role in preventing, diagnosing, and treating ocular diseases. For example, lowering the IOP is the primary focus of glaucoma management. However, IOP is a widely varying parameter, and one-off measurements are prompt to errors. Developing portable solutions for continuous monitoring the IOP is a critical goal in ophthalmology. Here, stretchable nanostructures were developed as strain-tunable diffraction gratings and integrated into a contact lens. They exhibited a limit of detection (LOD) <2 mmHg and a linear response in the range of interest (15-35 mmHg). Nanopatterns were characterized under monochromatic laser sources and further integrated into a soft contact lens. A smartphone readout method based on preferentially reflected colors was proposed to pave the way toward smartphone-based ocular health monitoring.
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Published date: 12 November 2021
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Keywords:
contact lenses, diffraction gratings, glaucoma, intraocular pressure (IOP), nanopillars
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Local EPrints ID: 503367
URI: http://eprints.soton.ac.uk/id/eprint/503367
ISSN: 2637-6105
PURE UUID: 0508d898-2970-4774-8435-283abf32b88f
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Date deposited: 29 Jul 2025 17:04
Last modified: 30 Jul 2025 02:14
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Contributors
Author:
Rosalia Moreddu
Author:
Nasim Mahmoodi
Author:
Panagiotis Kassanos
Author:
Daniele Vigolo
Author:
Paula M. Mendes
Author:
Ali K. Yetisen
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