Patient-reported real-world experience of risankizumab on-body device (OBD) for the treatment of Crohn’s disease in the UK (COMMODUS)
Patient-reported real-world experience of risankizumab on-body device (OBD) for the treatment of Crohn’s disease in the UK (COMMODUS)
Objective: to evaluate real-world patient-reported experience with subcutaneous (SC) risankizumab administered by on-body device (OBD) in patients with Crohn’s disease (CD).
Methods: uncontrolled observational cross-sectional study in five UK units between October 2023 and May 2024. Patients who had received maintenance risankizumab via SC injection of four pre-filled syringes (PFS) self-administered in hospital were switched to OBD self-injection. Self-Injection Assessment Questionnaires (SIAQ) were completed pre- and post-first OBD use. The primary end-point was “Overall, how satisfied are you with your current way of taking your medication (self-injection)?” from post-injection SIAQ. Baseline patient data were collected retrospectively from medical records.
Results: the study recruited 50 patients with moderate-to-severe CD, 48 completed the study. Most (81%) were satisfied/very satisfied with self-injection using OBD vs only 54% with PFS. Satisfaction with the OBD was highest with home use (90% vs 65%). Confidence was high with the OBD; numerically higher rates of patients were confident in giving themselves an injection in the right way (83% vs 64%), in a clean and sterile way (90% vs 74%) and safely (85% vs 72%) post-OBD than before using OBD. Self-injection using the OBD was reported as easy by 92% and convenient by 83% of participants. Most participants reported that they would continue to use the OBD (82%) and be confident to self-inject at home (81%). The OBD was well tolerated.
Conclusion: the OBD provides a safe, easy to use and convenient way to self-administer risankizumab at home using one injection with improved satisfaction and confidence vs self-administration of four PFS in hospital.
Crohn’s disease, Risankizumab, SIAQ, on-body injector, patient reported outcomes, patient satisfaction
829-839
Jaulim, Adil
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Stanton, Anna
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Tripoli, Sherill
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Ibarra, Ana
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Young, David
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Doona, Mary
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Cummings, Fraser
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Speight, Ally
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Din, Shahida
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Lindsay, James O.
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Horsfall, Rachel
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Sephton, Mark
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Samaan, Mark A.
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Jaulim, Adil
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Stanton, Anna
47e71007-1785-4ef8-82a8-a4f79c0860df
Tripoli, Sherill
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Ibarra, Ana
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Young, David
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Doona, Mary
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Cummings, Fraser
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Speight, Ally
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Din, Shahida
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Lindsay, James O.
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Horsfall, Rachel
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Sephton, Mark
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Samaan, Mark A.
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Jaulim, Adil, Stanton, Anna, Tripoli, Sherill, Ibarra, Ana, Young, David, Doona, Mary, Cummings, Fraser, Speight, Ally, Din, Shahida, Lindsay, James O., Horsfall, Rachel, Sephton, Mark and Samaan, Mark A.
(2025)
Patient-reported real-world experience of risankizumab on-body device (OBD) for the treatment of Crohn’s disease in the UK (COMMODUS).
Current Medical Research and Opinion, 41 (5), .
(doi:10.1080/03007995.2025.2506808).
Abstract
Objective: to evaluate real-world patient-reported experience with subcutaneous (SC) risankizumab administered by on-body device (OBD) in patients with Crohn’s disease (CD).
Methods: uncontrolled observational cross-sectional study in five UK units between October 2023 and May 2024. Patients who had received maintenance risankizumab via SC injection of four pre-filled syringes (PFS) self-administered in hospital were switched to OBD self-injection. Self-Injection Assessment Questionnaires (SIAQ) were completed pre- and post-first OBD use. The primary end-point was “Overall, how satisfied are you with your current way of taking your medication (self-injection)?” from post-injection SIAQ. Baseline patient data were collected retrospectively from medical records.
Results: the study recruited 50 patients with moderate-to-severe CD, 48 completed the study. Most (81%) were satisfied/very satisfied with self-injection using OBD vs only 54% with PFS. Satisfaction with the OBD was highest with home use (90% vs 65%). Confidence was high with the OBD; numerically higher rates of patients were confident in giving themselves an injection in the right way (83% vs 64%), in a clean and sterile way (90% vs 74%) and safely (85% vs 72%) post-OBD than before using OBD. Self-injection using the OBD was reported as easy by 92% and convenient by 83% of participants. Most participants reported that they would continue to use the OBD (82%) and be confident to self-inject at home (81%). The OBD was well tolerated.
Conclusion: the OBD provides a safe, easy to use and convenient way to self-administer risankizumab at home using one injection with improved satisfaction and confidence vs self-administration of four PFS in hospital.
Text
Patient-reported real-world experience of risankizumab on-body device OBD for the treatment of Crohn s disease in the UK COMMODUS
- Version of Record
More information
Accepted/In Press date: 12 May 2025
e-pub ahead of print date: 23 May 2025
Keywords:
Crohn’s disease, Risankizumab, SIAQ, on-body injector, patient reported outcomes, patient satisfaction
Identifiers
Local EPrints ID: 503469
URI: http://eprints.soton.ac.uk/id/eprint/503469
ISSN: 0300-7995
PURE UUID: abcda88b-8a27-4c8d-be57-0ec7640be0a9
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Date deposited: 01 Aug 2025 16:45
Last modified: 22 Aug 2025 02:34
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Contributors
Author:
Adil Jaulim
Author:
Anna Stanton
Author:
Sherill Tripoli
Author:
Ana Ibarra
Author:
David Young
Author:
Mary Doona
Author:
Fraser Cummings
Author:
Ally Speight
Author:
Shahida Din
Author:
James O. Lindsay
Author:
Rachel Horsfall
Author:
Mark Sephton
Author:
Mark A. Samaan
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