Investigating the degradation properties of poly(ε-caprolactone) and polyethylene terephthalate glycol as biomaterials

Hou, Yanhao, Wang, Weiguang and Bartolo, Paulo (2023) Investigating the degradation properties of poly(ε-caprolactone) and polyethylene terephthalate glycol as biomaterials. In Progress in Digital and Physical Manufacturing : Proceedings of ProDPM’21. Springer.. (doi:10.1007/978-3-031-33890-8_35).

Record type: Conference or Workshop Item (Paper)

Abstract

Represented by three-dimensional (3D) scaffolds, artificial implants have been widely investigated for bone tissue engineering applications. The properties of these biocompatible and biodegradable scaffolds highly depend on the materials, processing conditions, and structure. Biodegradability is one of the most important properties of the scaffolds, which affect both biological and mechanical performance after implantation. Poly(ε-caprolactone) (PCL) is a type of relevantly mature material that has been widely used for scaffolds fabrication and polyethylene terephthalate glycol (PETG) is a newly proposed biomaterial for bone tissue engineering. This paper investigates the degradation profile of both PCL and PETG scaffolds. The effect of degradation on morphology and mechanical behaviours are also evaluated. Results showed that PCL scaffolds have a faster degradation rate and lower mechanical properties comparing with PETG scaffolds, and the mechanical properties decreased with time.

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