Chronic cerebrospinal fluid leak into skull base causing intramedullary osteolysis
Chronic cerebrospinal fluid leak into skull base causing intramedullary osteolysis
We present the rare case of a 74-year-old woman with extensive intramedullary osteolysis of the petroclival skull base straddling both sides of the basi-occiput and basi-sphenoid. She presented with clinical features of recurrent spontaneous cerebrospinal fluid (CSF) otorrhoea despite three previous attempts at repair of the CSF leak. Recent advances in imaging techniques enable accurate radiological diagnosis of skull base lesions. We performed T1- and T2-weighted magnetic resonance (MR) images, a fluid attenuated inversion recovery (FLAIR) sequence MR, and a diffusion scan to study the characteristics of the skull base pathology. This revealed extensive osteolysis, with cystic spaces within the clivus and the petrous pyramid extending also to the basi-occiput. The leak was sealed using the technique of subtotal petrosectomy with obliteration of the eustachian tube and blind pit closure of the ear canal. The patient has been followed up for six months with no recurrence of symptoms.
Aged, Cerebrospinal Fluid Otorrhea/complications, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Osteolysis/diagnosis, Skull Base/pathology, Tomography, X-Ray Computed
888-890
Dutt, S N
42357d45-76b0-4d24-bc4b-037273f8e648
Salib, R J
d6fde1c1-5b5e-43f7-ae1c-42cce6a0c9fc
Chavda, S V
6b5213c3-f8a1-4483-ad13-7e275f61211c
Irving, R M
49eec8b7-cef4-42bc-bfdc-277e6504f266
November 2000
Dutt, S N
42357d45-76b0-4d24-bc4b-037273f8e648
Salib, R J
d6fde1c1-5b5e-43f7-ae1c-42cce6a0c9fc
Chavda, S V
6b5213c3-f8a1-4483-ad13-7e275f61211c
Irving, R M
49eec8b7-cef4-42bc-bfdc-277e6504f266
Dutt, S N, Salib, R J, Chavda, S V and Irving, R M
(2000)
Chronic cerebrospinal fluid leak into skull base causing intramedullary osteolysis.
The Journal of Laryngology & Otology, 114 (11), .
(doi:10.1258/0022215001904275).
Abstract
We present the rare case of a 74-year-old woman with extensive intramedullary osteolysis of the petroclival skull base straddling both sides of the basi-occiput and basi-sphenoid. She presented with clinical features of recurrent spontaneous cerebrospinal fluid (CSF) otorrhoea despite three previous attempts at repair of the CSF leak. Recent advances in imaging techniques enable accurate radiological diagnosis of skull base lesions. We performed T1- and T2-weighted magnetic resonance (MR) images, a fluid attenuated inversion recovery (FLAIR) sequence MR, and a diffusion scan to study the characteristics of the skull base pathology. This revealed extensive osteolysis, with cystic spaces within the clivus and the petrous pyramid extending also to the basi-occiput. The leak was sealed using the technique of subtotal petrosectomy with obliteration of the eustachian tube and blind pit closure of the ear canal. The patient has been followed up for six months with no recurrence of symptoms.
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Published date: November 2000
Keywords:
Aged, Cerebrospinal Fluid Otorrhea/complications, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Osteolysis/diagnosis, Skull Base/pathology, Tomography, X-Ray Computed
Identifiers
Local EPrints ID: 503732
URI: http://eprints.soton.ac.uk/id/eprint/503732
ISSN: 0022-2151
PURE UUID: 7840ea27-e85f-42c4-b064-743499f3419a
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Date deposited: 12 Aug 2025 16:40
Last modified: 13 Aug 2025 02:00
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Author:
S N Dutt
Author:
S V Chavda
Author:
R M Irving
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