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SchizConnect: virtual data integration in neuroimaging

SchizConnect: virtual data integration in neuroimaging
SchizConnect: virtual data integration in neuroimaging
In many scientific domains, including neuroimaging studies, there is a need to obtain increasingly larger cohorts to achieve the desired statistical power for discovery. However, the economics of imaging studies make it unlikely that any single study or consortia can achieve the desired sample sizes. What is needed is an architecture that can easily incorporate additional studies as they become available. We present such architecture based on a virtual data integration approach, where data remains at the original sources, and is retrieved and harmonized in response to user queries. This is in contrast to approaches that move the data to a central warehouse. We implemented our approach in the SchizConnect system that integrates data from three neuroimaging consortia on Schizophrenia: FBIRN’s Human Imaging Database (HID), MRN’s Collaborative Imaging and Neuroinformatics System (COINS), and the NUSDAST project at XNAT Central. A portal providing harmonized access to these sources is publicly deployed at schizconnect.org.
37-51
Ambite, Jose Luis
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Tallis, Marcelo
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Alpert, Kathryn
bf83d9c8-5fd0-47e3-86bc-156a6b24e236
Keator, David
ff05ddc8-2458-481e-9bd3-13382ff7c69e
King, Margaret
acc1ebfd-1ccb-448e-8279-b59114b5bf3e
Landis, Drew
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Konstantinidis, George
f174fb99-8434-4485-a7e4-bee0fef39b42
Calhoun, Vince D.
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Potkin, Steven
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Turner, Jessica
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Wang, Lei
eca28794-ded4-4994-a126-27ab4c54637c
Ambite, Jose Luis
0a7ecac4-d15d-47c9-ac49-c06d8525f9d7
Tallis, Marcelo
34ac9f46-5cda-4871-9916-de51827c56f8
Alpert, Kathryn
bf83d9c8-5fd0-47e3-86bc-156a6b24e236
Keator, David
ff05ddc8-2458-481e-9bd3-13382ff7c69e
King, Margaret
acc1ebfd-1ccb-448e-8279-b59114b5bf3e
Landis, Drew
457c0c94-a927-40d3-b159-3a7b353d0d05
Konstantinidis, George
f174fb99-8434-4485-a7e4-bee0fef39b42
Calhoun, Vince D.
6870f108-a80e-41d7-961b-2f83bba119e5
Potkin, Steven
e6ab293a-87dc-4bf8-9005-18266cf5a351
Turner, Jessica
636dc25f-c8b5-4190-a1d9-09c7893db028
Wang, Lei
eca28794-ded4-4994-a126-27ab4c54637c

Ambite, Jose Luis, Tallis, Marcelo, Alpert, Kathryn, Keator, David, King, Margaret, Landis, Drew, Konstantinidis, George, Calhoun, Vince D., Potkin, Steven, Turner, Jessica and Wang, Lei (2015) SchizConnect: virtual data integration in neuroimaging. 11th International Conference on Data Integration in the Life Sciences, , Los Angeles, United States. 09 - 10 Jul 2015. pp. 37-51 .

Record type: Conference or Workshop Item (Paper)

Abstract

In many scientific domains, including neuroimaging studies, there is a need to obtain increasingly larger cohorts to achieve the desired statistical power for discovery. However, the economics of imaging studies make it unlikely that any single study or consortia can achieve the desired sample sizes. What is needed is an architecture that can easily incorporate additional studies as they become available. We present such architecture based on a virtual data integration approach, where data remains at the original sources, and is retrieved and harmonized in response to user queries. This is in contrast to approaches that move the data to a central warehouse. We implemented our approach in the SchizConnect system that integrates data from three neuroimaging consortia on Schizophrenia: FBIRN’s Human Imaging Database (HID), MRN’s Collaborative Imaging and Neuroinformatics System (COINS), and the NUSDAST project at XNAT Central. A portal providing harmonized access to these sources is publicly deployed at schizconnect.org.

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More information

Published date: 8 July 2015
Venue - Dates: 11th International Conference on Data Integration in the Life Sciences, , Los Angeles, United States, 2015-07-09 - 2015-07-10

Identifiers

Local EPrints ID: 504285
URI: http://eprints.soton.ac.uk/id/eprint/504285
PURE UUID: 644959de-f46c-4f4d-8054-92eb612f6843

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Date deposited: 02 Sep 2025 17:09
Last modified: 02 Sep 2025 17:09

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Contributors

Author: Jose Luis Ambite
Author: Marcelo Tallis
Author: Kathryn Alpert
Author: David Keator
Author: Margaret King
Author: Drew Landis
Author: George Konstantinidis
Author: Vince D. Calhoun
Author: Steven Potkin
Author: Jessica Turner
Author: Lei Wang

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