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Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion

Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion
Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion
Effects of thalamic nuclei damage and related white matter tracts on memory performance are still debated. This is particularly evident for the medio-dorsal thalamus which has been less clear in predicting amnesia than anterior thalamus changes. The current study addresses this issue by assessing 7 thalamic stroke patients with consistent unilateral lesions focal to the left medio-dorsal nuclei for immediate and delayed memory performance on standard visual and verbal tests of anterograde memory, and over the long-term (>24 h) on an object-location associative memory task. Thalamic patients showed selective impairment to delayed recall, but intact recognition memory. Patients also showed accelerated forgetting of contextual details after a 24 h delay, compared to controls. Importantly, the mammillothalamic tract was intact in all patients, which suggests a role for the medio-dorsal nuclei in recall and early consolidation memory processes.
1662-5153
Tu, Sicong
c6d2f218-6145-4557-9e8b-8ae2ba4b0d0f
Miller, Laurie
6067f8e7-c170-4f59-ba3d-f827d49860e5
Piguet, Olivier
f55e7f2d-22d5-40bf-8607-5db4850801b6
Hornberger, Michael
a48c1c63-422a-4c11-9a51-c7be0aa3026d
Tu, Sicong
c6d2f218-6145-4557-9e8b-8ae2ba4b0d0f
Miller, Laurie
6067f8e7-c170-4f59-ba3d-f827d49860e5
Piguet, Olivier
f55e7f2d-22d5-40bf-8607-5db4850801b6
Hornberger, Michael
a48c1c63-422a-4c11-9a51-c7be0aa3026d

Tu, Sicong, Miller, Laurie, Piguet, Olivier and Hornberger, Michael (2014) Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion. Frontiers in Behavioral Neuroscience, 8. (doi:10.3389/fnbeh.2014.00320).

Record type: Article

Abstract

Effects of thalamic nuclei damage and related white matter tracts on memory performance are still debated. This is particularly evident for the medio-dorsal thalamus which has been less clear in predicting amnesia than anterior thalamus changes. The current study addresses this issue by assessing 7 thalamic stroke patients with consistent unilateral lesions focal to the left medio-dorsal nuclei for immediate and delayed memory performance on standard visual and verbal tests of anterograde memory, and over the long-term (>24 h) on an object-location associative memory task. Thalamic patients showed selective impairment to delayed recall, but intact recognition memory. Patients also showed accelerated forgetting of contextual details after a 24 h delay, compared to controls. Importantly, the mammillothalamic tract was intact in all patients, which suggests a role for the medio-dorsal nuclei in recall and early consolidation memory processes.

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e-pub ahead of print date: 15 September 2014

Identifiers

Local EPrints ID: 504526
URI: http://eprints.soton.ac.uk/id/eprint/504526
ISSN: 1662-5153
PURE UUID: fde8d340-d846-457e-9ccb-40eefc7c252a
ORCID for Michael Hornberger: ORCID iD orcid.org/0000-0002-2214-3788

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Date deposited: 12 Sep 2025 16:43
Last modified: 13 Sep 2025 02:41

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Contributors

Author: Sicong Tu
Author: Laurie Miller
Author: Olivier Piguet
Author: Michael Hornberger ORCID iD

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