Understanding placebo mechanisms to reduce attrition in psychiatric trials
Understanding placebo mechanisms to reduce attrition in psychiatric trials
Placebo responses in psychiatric trials are clinically significant and variable.1 When placebo response is large, the assay sensitivity of a clinical trial can be impacted, meaning that it can potentially result in a failure to detect efficacy for an active treatment.2 The constituent effects that combine to produce a placebo response are multiple and include both specific placebo mechanisms (eg, expectation effects) and nonspecific effects (eg, regression to the mean).1,3 An additional factor that might impact estimates of both treatment and placebo response is missing data.
553-554
Huneke, Nathan T.M.
7e4a84ba-5aed-4966-adf2-58a92a0b4284
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Solmi, Marco
2022a2e4-774d-4811-b1db-b6dbfedbd10d
4 June 2025
Huneke, Nathan T.M.
7e4a84ba-5aed-4966-adf2-58a92a0b4284
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Solmi, Marco
2022a2e4-774d-4811-b1db-b6dbfedbd10d
Huneke, Nathan T.M., Cortese, Samuele and Solmi, Marco
(2025)
Understanding placebo mechanisms to reduce attrition in psychiatric trials.
JAMA Psychiatry, 82 (6), .
(doi:10.1001/jamapsychiatry.2025.0303).
Abstract
Placebo responses in psychiatric trials are clinically significant and variable.1 When placebo response is large, the assay sensitivity of a clinical trial can be impacted, meaning that it can potentially result in a failure to detect efficacy for an active treatment.2 The constituent effects that combine to produce a placebo response are multiple and include both specific placebo mechanisms (eg, expectation effects) and nonspecific effects (eg, regression to the mean).1,3 An additional factor that might impact estimates of both treatment and placebo response is missing data.
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e-pub ahead of print date: 16 April 2025
Published date: 4 June 2025
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Local EPrints ID: 504679
URI: http://eprints.soton.ac.uk/id/eprint/504679
ISSN: 2168-622X
PURE UUID: 3c86b8c0-acd2-4840-9a66-0a9d4d1bebf5
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Date deposited: 17 Sep 2025 16:55
Last modified: 18 Sep 2025 02:00
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Author:
Nathan T.M. Huneke
Author:
Marco Solmi
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