Mediterranean diet adherence and cognitive function in older UK adults: the European prospective investigation into cancer and nutrition-Norfolk (EPIC-Norfolk) study

OM, Shannon, BCM, Stephan, Granic, A, Lentjes, M, Hayat, S, Mulligan, A, Brayne, C, KT, Khaw, Bundy, R, Aldred, S, Hornberger, M, SM, Paddick, Muniz-Tererra, G and Siervo, M (2019) Mediterranean diet adherence and cognitive function in older UK adults: the European prospective investigation into cancer and nutrition-Norfolk (EPIC-Norfolk) study. The American Journal of Clinical Nutrition, 110 (4), 938-948. (doi:10.1093/ajcn/nqz114).

Abstract

Background
In Mediterranean countries, adherence to a traditional Mediterranean dietary pattern (MedDiet) is associated with better cognitive function and reduced dementia risk. It is unclear if similar benefits exist in non-Mediterranean regions.

Objectives
The aims of this study were to examine associations between MedDiet adherence and cognitive function in an older UK population and to investigate whether associations differed between individuals with high compared with low cardiovascular disease (CVD) risk.

Methods
We conducted an analysis in 8009 older individuals with dietary data at Health Check 1 (1993–1997) and cognitive function data at Health Check 3 (2006–2011) of the European Prospective Investigation into Cancer and Nutrition–Norfolk (EPIC-Norfolk). Associations were explored between MedDiet adherence and global and domain-specific cognitive test scores and risk of poor cognitive performance in the entire cohort, and when stratified according to CVD risk status.

Results
Higher MedDiet adherence defined by the Pyramid MedDiet score was associated with better global cognition (β ± SE = −0.012 ± 0.002; P < 0.001), verbal episodic memory (β ± SE = −0.009 ± 0.002; P < 0.001), and simple processing speed (β ± SE = −0.002 ± 0.001; P = 0.013). Lower risk of poor verbal episodic memory (OR: 0.784; 95% CI: 0.641, 0.959; P = 0.018), complex processing speed (OR: 0.739; 95% CI: 0.601, 0.907; P = 0.004), and prospective memory (OR: 0.841; 95% CI: 0.724, 0.977; P = 0.023) was also observed for the highest compared with the lowest Pyramid MedDiet tertiles. The effect of a 1-point increase in Pyramid score on global cognitive function was equivalent to 1.7 fewer years of cognitive aging. MedDiet adherence defined by the Mediterranean Diet Adherence Screener (MEDAS) score (mapped through the use of both binary and continuous scoring) showed similar, albeit less consistent, associations. In stratified analyses, associations were evident in individuals at higher CVD risk only (P < 0.05).

Conclusions
Higher adherence to the MedDiet is associated with better cognitive function and lower risk of poor cognition in older UK adults. This evidence underpins the development of interventions to enhance MedDiet adherence, particularly in individuals at higher CVD risk, aiming to reduce the risk of age-related cognitive decline in non-Mediterranean populations.

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Contributors

Author: M Hornberger

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