Memory and orientation in the logopenic and nonfluent subtypes of primary progressive aphasia

EC, Flanagan, Tu, S, Ahmed, S, JR, Hodges and Hornberger, M (2014) Memory and orientation in the logopenic and nonfluent subtypes of primary progressive aphasia. Journal of Alzheimer's Disease : JAD, 40 (1), 33-36. (doi:10.3233/jad-131448).

Record type: Article

Abstract

Memory and orientation were investigated as predictors of underlying Alzheimer's disease (AD) pathology in patients with logopenic (lv) and non-fluent (na) variants of primary progressive aphasia (PPA). Memory and orientation scores from Addenbrooke's Cognitive Examination were compared between 26 lv-PPA, 29 na-PPA, 59 AD, and 90 controls using analysis of variance. Forty-five patients underwent Pittsburgh compound B (PiB) positron emission tomography scans. Patients with lv-PPA performed poorer on memory and orientation than na-PPA and did not differ from the AD group. Post-hoc analysis on the PiB-scanned subgroup corroborated these results. Memory and orientation profiles may supplement language assessment in identifying patients with AD pathology.

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