Clinical Profile of PiB-Positive Corticobasal Syndrome
Clinical Profile of PiB-Positive Corticobasal Syndrome
Background
Corticobasal syndrome (CBS) is a multifaceted neurodegenerative disorder characterized by a combination of motor and cognitive deficits. Several different pathological entities, including Alzheimer’s pathology, have been described in association with CBS. The present study aimed to establish clinical, neuropsychological, and neuroimaging features that could be useful in the distinction of CBS due to AD pathology from other CBS cases in life based on [11C] Pittsburgh Compound B positron emission tomography (PiB-PET) status.
Methods
Patients with CBS were prospectively recruited from a specialized cognitive disorders clinic. All patients underwent detailed clinical and neuropsychological assessment, with structural imaging using voxel-based analysis of magnetic resonance imaging. Alzheimer’s pathology was detected using PiB-PET imaging, and PiB-positive and PiB-negative groups were compared.
Results
Fourteen CBS patients meeting defined criteria were included (7 male, 7 female; mean age 66.1+/−6.9 years; median symptom duration was 35.5+/−22.6 months) and compared to 20 matched control subjects. Of the 14 patients, 4 were PiB-positive and 10 PiB-negative. There were no significant differences between PiB-positive and PiB-negative CBS patients in age, gender, education, symptom duration, or motor features. PiB-positive patients had greater visuospatial deficits, a higher rate of sentence repetition impairment, and more functional decline. Voxel-based morphometry analyses demonstrated extensive peri-insular and post-central atrophy in both groups, but PiB-positive patients had atrophy that extended to include the posterior part of the left superior temporal gyrus.
Conclusions
Visuospatial function, aspects of language, and the pattern of cerebral atrophy may be useful in distinguishing patients with CBS due to underlying AD pathology.
Burrell, James R.
c3839d64-215c-4e62-933c-9ccbd05e1b3b
Hornberger, Michael
a48c1c63-422a-4c11-9a51-c7be0aa3026d
Villemagne, Victor L.
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Rowe, Christopher C.
09337b37-3f36-4a87-9fde-1a7a46d33d38
Hodges, John R.
7e7a95ab-a65f-42a1-8c01-30917e6b2f3d
5 April 2013
Burrell, James R.
c3839d64-215c-4e62-933c-9ccbd05e1b3b
Hornberger, Michael
a48c1c63-422a-4c11-9a51-c7be0aa3026d
Villemagne, Victor L.
7fecc645-228b-42b7-be2b-91eab34abfc7
Rowe, Christopher C.
09337b37-3f36-4a87-9fde-1a7a46d33d38
Hodges, John R.
7e7a95ab-a65f-42a1-8c01-30917e6b2f3d
Burrell, James R., Hornberger, Michael, Villemagne, Victor L., Rowe, Christopher C. and Hodges, John R.
(2013)
Clinical Profile of PiB-Positive Corticobasal Syndrome.
PLoS ONE, 8 (4).
(doi:10.1371/journal.pone.0061025).
Abstract
Background
Corticobasal syndrome (CBS) is a multifaceted neurodegenerative disorder characterized by a combination of motor and cognitive deficits. Several different pathological entities, including Alzheimer’s pathology, have been described in association with CBS. The present study aimed to establish clinical, neuropsychological, and neuroimaging features that could be useful in the distinction of CBS due to AD pathology from other CBS cases in life based on [11C] Pittsburgh Compound B positron emission tomography (PiB-PET) status.
Methods
Patients with CBS were prospectively recruited from a specialized cognitive disorders clinic. All patients underwent detailed clinical and neuropsychological assessment, with structural imaging using voxel-based analysis of magnetic resonance imaging. Alzheimer’s pathology was detected using PiB-PET imaging, and PiB-positive and PiB-negative groups were compared.
Results
Fourteen CBS patients meeting defined criteria were included (7 male, 7 female; mean age 66.1+/−6.9 years; median symptom duration was 35.5+/−22.6 months) and compared to 20 matched control subjects. Of the 14 patients, 4 were PiB-positive and 10 PiB-negative. There were no significant differences between PiB-positive and PiB-negative CBS patients in age, gender, education, symptom duration, or motor features. PiB-positive patients had greater visuospatial deficits, a higher rate of sentence repetition impairment, and more functional decline. Voxel-based morphometry analyses demonstrated extensive peri-insular and post-central atrophy in both groups, but PiB-positive patients had atrophy that extended to include the posterior part of the left superior temporal gyrus.
Conclusions
Visuospatial function, aspects of language, and the pattern of cerebral atrophy may be useful in distinguishing patients with CBS due to underlying AD pathology.
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Accepted/In Press date: 5 March 2013
Published date: 5 April 2013
Identifiers
Local EPrints ID: 505127
URI: http://eprints.soton.ac.uk/id/eprint/505127
ISSN: 1932-6203
PURE UUID: c73f2d44-042b-4a54-b290-f7eb855c0599
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Date deposited: 29 Sep 2025 17:50
Last modified: 30 Sep 2025 02:25
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Contributors
Author:
James R. Burrell
Author:
Michael Hornberger
Author:
Victor L. Villemagne
Author:
Christopher C. Rowe
Author:
John R. Hodges
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