Longitudinal changes in tat mass and the Hippocampus
Longitudinal changes in tat mass and the Hippocampus
Objective
This study aimed to investigate cross-sectional and longitudinal associations between fat mass (i.e., body mass index [BMI], waist circumference [WC], and waist to hip ratio [WTHR]) and hippocampal volumes.
Methods
UK Biobank participants (N = 20,395) aged 40 to 70 years (mean follow-up = 7.66 years), were included and categorized into one of four groups, which represented their baseline fat mass status and trajectory of change by follow-up assessment: normal weight to overweight/obesity, overweight/obesity to normal weight (ON), normal weight stable (NS), or overweight/obesity stable (OS). Regression models used NS (WC < 80 cm in women and < 94 cm in men; WTHR < 0.85 in women and < 0.90 in men; BMI < 25 kg/m2 in women and men) as the reference group. Hippocampal volumes were automatically segmented using the FMRIB Software Library.
Results
Compared with NS, OS (BMI: B = −62.23 [SE = 16.76]; WC: B = −145.56 [SE = 16.97]; WTHR: B = −101.26 [SE = 19.54]) and ON (BMI: B = −61.1 [SE = 30.3]; WC: B = −93.77 [SE = 24.96]; WTHR: B = −69.92 [SE = 26.22]) had significantly lower hippocampal volumes.
Conclusions
The detrimental effects of overweight/obesity may extend beyond the duration of overweight/obesity itself.
1263-1269
Ambikairajah, A
d6f3d544-28fd-4111-8148-d8a057f85c85
Tabatabaei-Jafari, H
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Walsh, E
458e5542-ac00-41e8-b88f-c185c1e03511
Hornberger, M
a48c1c63-422a-4c11-9a51-c7be0aa3026d
Cherbuin, N
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Ambikairajah, A
d6f3d544-28fd-4111-8148-d8a057f85c85
Tabatabaei-Jafari, H
d914f80d-4d51-4c1f-bd52-2d13c2622861
Walsh, E
458e5542-ac00-41e8-b88f-c185c1e03511
Hornberger, M
a48c1c63-422a-4c11-9a51-c7be0aa3026d
Cherbuin, N
3b6d40fe-c22c-4592-afda-2df111aa2dda
Ambikairajah, A, Tabatabaei-Jafari, H, Walsh, E, Hornberger, M and Cherbuin, N
(2020)
Longitudinal changes in tat mass and the Hippocampus.
Obesity (Silver Spring, Md.), 28 (7), .
(doi:10.1002/oby.22819).
Abstract
Objective
This study aimed to investigate cross-sectional and longitudinal associations between fat mass (i.e., body mass index [BMI], waist circumference [WC], and waist to hip ratio [WTHR]) and hippocampal volumes.
Methods
UK Biobank participants (N = 20,395) aged 40 to 70 years (mean follow-up = 7.66 years), were included and categorized into one of four groups, which represented their baseline fat mass status and trajectory of change by follow-up assessment: normal weight to overweight/obesity, overweight/obesity to normal weight (ON), normal weight stable (NS), or overweight/obesity stable (OS). Regression models used NS (WC < 80 cm in women and < 94 cm in men; WTHR < 0.85 in women and < 0.90 in men; BMI < 25 kg/m2 in women and men) as the reference group. Hippocampal volumes were automatically segmented using the FMRIB Software Library.
Results
Compared with NS, OS (BMI: B = −62.23 [SE = 16.76]; WC: B = −145.56 [SE = 16.97]; WTHR: B = −101.26 [SE = 19.54]) and ON (BMI: B = −61.1 [SE = 30.3]; WC: B = −93.77 [SE = 24.96]; WTHR: B = −69.92 [SE = 26.22]) had significantly lower hippocampal volumes.
Conclusions
The detrimental effects of overweight/obesity may extend beyond the duration of overweight/obesity itself.
Text
Obesity - 2020 - Ambikairajah - Longitudinal Changes in Fat Mass and the Hippocampus
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Accepted/In Press date: 30 March 2020
e-pub ahead of print date: 19 May 2020
Identifiers
Local EPrints ID: 505236
URI: http://eprints.soton.ac.uk/id/eprint/505236
ISSN: 1930-7381
PURE UUID: 3fc03a19-b76e-45ba-8253-2c5b11985227
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Date deposited: 02 Oct 2025 16:49
Last modified: 04 Oct 2025 02:20
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Contributors
Author:
A Ambikairajah
Author:
H Tabatabaei-Jafari
Author:
E Walsh
Author:
M Hornberger
Author:
N Cherbuin
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