Cut-off scores for mild and moderate dementia on the Addenbrooke's cognitive examination-III and the mini-Addenbrooke's cognitive examination compared with the mini-mental state examination

McCarthy, Louise, Rubinsztein, Judy, Lowry, Ellen, Flanagan, Emma, Menon, Vandana, Vearncombe, Silvia, Mioshi, Eneida and Hornberger, Michael (2024) Cut-off scores for mild and moderate dementia on the Addenbrooke's cognitive examination-III and the mini-Addenbrooke's cognitive examination compared with the mini-mental state examination. BJPsych Bulletin, 48 (1), 12-18. (doi:10.1192/bjb.2023.27).

Abstract

AIMS AND METHOD: We aimed to establish cut-off scores to stage dementia on the Addenbrooke's Cognitive Examination-III (ACE-III) and the Mini-Addenbrooke's Cognitive Examination (M-ACE) compared with scores traditionally used with the Mini-Mental State Examination (MMSE). Our cross-sectional study recruited 80 patients and carers from secondary care services in the UK.

RESULTS: A score ≤76 on the ACE-III and ≤19 on the M-ACE correlated well with MMSE cut-offs for mild dementia, with a good fit on the receiver operating characteristic analysis for both the ACE-III and M-ACE. The cut-off for moderate dementia had lower sensitivity and specificity. There were low to moderate correlations between the cognitive scales and scales for everyday functioning and behaviour.

CLINICAL IMPLICATIONS: Our findings allow an objective interpretation of scores on the ACE-III and the M-ACE relative to the MMSE, which may be helpful for clinical services and research trials.

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Contributors

Author: Michael Hornberger

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