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Socio‐demographic and geographic disparities in HIV prevalence, HIV testing and treatment coverage: an analysis of 108 national household surveys in 33 African countries

Socio‐demographic and geographic disparities in HIV prevalence, HIV testing and treatment coverage: an analysis of 108 national household surveys in 33 African countries
Socio‐demographic and geographic disparities in HIV prevalence, HIV testing and treatment coverage: an analysis of 108 national household surveys in 33 African countries

Introduction: socio-demographic and geographic disparities in HIV prevalence, uptake of HIV testing and access to antiretroviral therapy (ART) persist in high HIV burden countries. Understanding demographic, spatial and temporal factors can guide interventions. 

Methods: we analysed 108 geo-referenced population-based surveys conducted over 2000–2023 across 33 African countries, involving 2.3 million respondents. Multilevel Bayesian logistic regression models assessed associations between HIV outcomes (HIV prevalence, recent HIV testing and ART coverage) and socio-demographic characteristics (age, education, place of residence, relative wealth), geographic location (country, district) and time trends. Separate models were estimated for men and women in central, eastern, southern and western Africa. 

Results: inequalities in HIV risk and access to testing and treatment services were driven by differences in educational attainment and within-country variations. In southern Africa, women with tertiary education had a 12%-point lower HIV prevalence (95% Credible Interval [CrI]: −27% to −2%) than those with less than primary education. In eastern Africa, they had a 13%-points (95% CrI: 2−22%) higher probability of recent HIV testing. Associations with relative wealth were weaker and more heterogeneous: in southern Africa, HIV prevalence shifted over time from higher to lower wealth quintiles, and adolescent girls and young women became the most frequently tested age group. In central Africa, wealthier men maintained higher recent testing and ART coverage levels. District-level variations accounted for disparities in HIV outcomes. In western Africa, the expected difference in ART coverage between individuals with similar socio-demographic characteristics living in different districts was 14%-points (95% CrI: 3−32%) for men and 10%-points (95% CrI: 3−27%) for women. 

Conclusions: disparities in HIV outcomes are strongly associated with differences in education, and across districts of the same country. Higher education levels are associated with lower HIV prevalence, greater testing and higher ART coverage, while districts with limited services sustain higher population viraemia. Despite the scale-up of HIV prevention and treatment programmes, important disparities remain, and renewed education-centred and geographically targeted efforts are needed to close gaps.

95-95-95, Bayesian statistics, HIV care cascade, HIV/AIDS, equity, sub-Saharan Africa
1758-2652
Allorant, Adrien
e5d1772b-fc28-4c3c-a62a-fec789c20b5f
Kuchukhidze, Salome
f09c5485-1722-4cb5-8c09-41422608e587
Stannah, James
392cd845-c331-4ebf-bca8-37491d4f78f5
Xia, Yiqing
e76b2d32-6ce4-47fd-8f41-1439b3a3abaa
Masuku, Sanele S.
4147ff77-ecd2-48c9-8daa-7b5b1f5b6ca8
Ekanmian, Gatien K.
c8e8a099-613f-4d35-8e22-eadae5eaf70e
Imai‐Eaton, Jeffrey W.
5f27d29e-f8ec-4138-b88d-34e89ad21a0a
Maheu‐Giroux, Mathieu
a1c33eef-0cc1-49c8-9075-36ba8c380965
Allorant, Adrien
e5d1772b-fc28-4c3c-a62a-fec789c20b5f
Kuchukhidze, Salome
f09c5485-1722-4cb5-8c09-41422608e587
Stannah, James
392cd845-c331-4ebf-bca8-37491d4f78f5
Xia, Yiqing
e76b2d32-6ce4-47fd-8f41-1439b3a3abaa
Masuku, Sanele S.
4147ff77-ecd2-48c9-8daa-7b5b1f5b6ca8
Ekanmian, Gatien K.
c8e8a099-613f-4d35-8e22-eadae5eaf70e
Imai‐Eaton, Jeffrey W.
5f27d29e-f8ec-4138-b88d-34e89ad21a0a
Maheu‐Giroux, Mathieu
a1c33eef-0cc1-49c8-9075-36ba8c380965

Allorant, Adrien, Kuchukhidze, Salome, Stannah, James, Xia, Yiqing, Masuku, Sanele S., Ekanmian, Gatien K., Imai‐Eaton, Jeffrey W. and Maheu‐Giroux, Mathieu (2025) Socio‐demographic and geographic disparities in HIV prevalence, HIV testing and treatment coverage: an analysis of 108 national household surveys in 33 African countries. Journal of the International AIDS Society, 28 (8), [e70024]. (doi:10.1002/jia2.70024).

Record type: Article

Abstract

Introduction: socio-demographic and geographic disparities in HIV prevalence, uptake of HIV testing and access to antiretroviral therapy (ART) persist in high HIV burden countries. Understanding demographic, spatial and temporal factors can guide interventions. 

Methods: we analysed 108 geo-referenced population-based surveys conducted over 2000–2023 across 33 African countries, involving 2.3 million respondents. Multilevel Bayesian logistic regression models assessed associations between HIV outcomes (HIV prevalence, recent HIV testing and ART coverage) and socio-demographic characteristics (age, education, place of residence, relative wealth), geographic location (country, district) and time trends. Separate models were estimated for men and women in central, eastern, southern and western Africa. 

Results: inequalities in HIV risk and access to testing and treatment services were driven by differences in educational attainment and within-country variations. In southern Africa, women with tertiary education had a 12%-point lower HIV prevalence (95% Credible Interval [CrI]: −27% to −2%) than those with less than primary education. In eastern Africa, they had a 13%-points (95% CrI: 2−22%) higher probability of recent HIV testing. Associations with relative wealth were weaker and more heterogeneous: in southern Africa, HIV prevalence shifted over time from higher to lower wealth quintiles, and adolescent girls and young women became the most frequently tested age group. In central Africa, wealthier men maintained higher recent testing and ART coverage levels. District-level variations accounted for disparities in HIV outcomes. In western Africa, the expected difference in ART coverage between individuals with similar socio-demographic characteristics living in different districts was 14%-points (95% CrI: 3−32%) for men and 10%-points (95% CrI: 3−27%) for women. 

Conclusions: disparities in HIV outcomes are strongly associated with differences in education, and across districts of the same country. Higher education levels are associated with lower HIV prevalence, greater testing and higher ART coverage, while districts with limited services sustain higher population viraemia. Despite the scale-up of HIV prevention and treatment programmes, important disparities remain, and renewed education-centred and geographically targeted efforts are needed to close gaps.

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Accepted/In Press date: 24 July 2025
Published date: 13 August 2025
Keywords: 95-95-95, Bayesian statistics, HIV care cascade, HIV/AIDS, equity, sub-Saharan Africa

Identifiers

Local EPrints ID: 505441
URI: http://eprints.soton.ac.uk/id/eprint/505441
ISSN: 1758-2652
PURE UUID: 65540799-2e52-4fc4-a54a-261031ba3139
ORCID for Adrien Allorant: ORCID iD orcid.org/0000-0002-9663-7561

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Date deposited: 08 Oct 2025 16:55
Last modified: 09 Oct 2025 02:22

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Contributors

Author: Adrien Allorant ORCID iD
Author: Salome Kuchukhidze
Author: James Stannah
Author: Yiqing Xia
Author: Sanele S. Masuku
Author: Gatien K. Ekanmian
Author: Jeffrey W. Imai‐Eaton
Author: Mathieu Maheu‐Giroux

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