Cholesterol and sterols in molluscan endocrinology: past, present, future
Cholesterol and sterols in molluscan endocrinology: past, present, future
Recently, critical evaluations have challenged the presence of vertebrate-type sex steroid signaling in mollusks, underlying the need of new research lines to shed light on molluscan endocrinology. The investigation of cholesterol metabolism and the potential biological role of sterols in mollusks has emerged as a growing research field in recent years. However, there is no clear consensus on several aspects of this topic and there is a great lack of relevant molecular data. In this perspective paper, we present an overview of our current knowledge on the role of cholesterol and sterols in mollusks and try to outline possible future research directions in molluscan endocrinology. Our study also provides a framework for studying cholesterol synthesis, uptake, transport, and metabolism in mollusks.
cholesterol, metabolism, mollusks, sex steroids, sterols, synthesis, transport
Fodor, István
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Markov, Gabriel V.
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Yañez-Guerra, Luis Alfonso
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Elekes, Károly
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Pollák, Edit
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Molnár, László
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Pirger, Zsolt
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31 July 2025
Fodor, István
a77c2b6a-30bb-4e5c-8fc8-f25013a21949
Markov, Gabriel V.
e9705499-fdf2-4846-b1d2-913be6547a01
Yañez-Guerra, Luis Alfonso
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Elekes, Károly
ce656fae-456b-4283-be4b-d5c41f369352
Pollák, Edit
bec1d51a-6a3b-4fde-9248-5e6e3c0d23be
Molnár, László
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Pirger, Zsolt
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Fodor, István, Markov, Gabriel V., Yañez-Guerra, Luis Alfonso, Elekes, Károly, Pollák, Edit, Molnár, László and Pirger, Zsolt
(2025)
Cholesterol and sterols in molluscan endocrinology: past, present, future.
Frontiers in Endocrinology, 16, [1627166].
(doi:10.3389/fendo.2025.1627166).
Abstract
Recently, critical evaluations have challenged the presence of vertebrate-type sex steroid signaling in mollusks, underlying the need of new research lines to shed light on molluscan endocrinology. The investigation of cholesterol metabolism and the potential biological role of sterols in mollusks has emerged as a growing research field in recent years. However, there is no clear consensus on several aspects of this topic and there is a great lack of relevant molecular data. In this perspective paper, we present an overview of our current knowledge on the role of cholesterol and sterols in mollusks and try to outline possible future research directions in molluscan endocrinology. Our study also provides a framework for studying cholesterol synthesis, uptake, transport, and metabolism in mollusks.
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fendo-16-1627166
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Accepted/In Press date: 14 July 2025
Published date: 31 July 2025
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Copyright © 2025 Fodor, Markov, Yañez-Guerra, Elekes, Pollák, Molnár and Pirger.
Keywords:
cholesterol, metabolism, mollusks, sex steroids, sterols, synthesis, transport
Identifiers
Local EPrints ID: 505627
URI: http://eprints.soton.ac.uk/id/eprint/505627
ISSN: 1664-2392
PURE UUID: 6f26525a-fb94-432a-b5a7-4e7f3171835d
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Date deposited: 14 Oct 2025 17:00
Last modified: 15 Oct 2025 02:11
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Contributors
Author:
István Fodor
Author:
Gabriel V. Markov
Author:
Luis Alfonso Yañez-Guerra
Author:
Károly Elekes
Author:
Edit Pollák
Author:
László Molnár
Author:
Zsolt Pirger
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