Modelling of cardiac biventricular electromechanics with coronary blood flow to investigate the influence of coronary arterial motion on coronary haemodynamic
Modelling of cardiac biventricular electromechanics with coronary blood flow to investigate the influence of coronary arterial motion on coronary haemodynamic
Background and objective: coronary flow is strongly influenced by the geometry and motion of coronary arteries, which change periodically in response to myocardial contraction throughout the cardiac cycle. However, a computational framework integrating cardiac biventricular electromechanics with dynamic coronary artery flow using a simplified, yet comprehensive mathematical approach remains underexplored. This study aims to develop a coupled 3D model of cardiac biventricular electromechanics and coronary circulation, enabling simulation of the interplay between cardiac electrical activity, mechanical function and coronary flow.
Methods: a patient-specific biventricular electromechanical model encompasses the fibre orientation, electrophysiology, mechanical properties and an open-loop heart circulation is developed. The electromechanical model is simulated independently from the coronary circulation model. The model provides an input for the Navier-Stokes-based coronary flow model. A one-way coupling approach maps the biventricular motion to the coronary arteries, linking both components. To evaluate the influence of coronary arterial motion on coronary haemodynamic, simulations are performed for two scenarios: a moving and a non-moving (static) coronary artery model.
Results: cardiac-induced coronary motion alters the pressure, velocity and flow profiles. Non-moving coronary arteries produce stable counter-rotating Dean-like vortices due to steady flow dominated by centrifugal forces, while the moving arteries disrupt these vortices as arterial curvature changes disturb the flow. Coronary motion significantly affects the wall shear stress, highlighting the necessity of incorporating arterial dynamics to investigate atherosclerosis.
Conclusion: the integrated biventricular-coronary model emphasizes the significance of background cardiac motion in coronary haemodynamic. The model offers a foundation for exploring myocardial perfusion mechanisms in realistic physiological settings.
Cardiac electromechanics, Cardiac motion, Cardiac-coronary coupling, Coronary blood flow, Myocardial perfusion
Binti Ulta Delestri, Laila Fadhillah
6634334f-4d49-494a-a674-1874f4374d6a
Amr Al Abed,
92859790-6c3e-45a1-a6df-61ffef8ed9ec
Socrates Dokos,
5dc0e9f4-e613-4d93-8023-deaed43b2ff6
Mohamed Mokhtarudin, Mohd Jamil
71fdd149-fb8a-4d36-9bea-0a2241b801f0
Kok, Foo Ngai
9c965216-c916-493c-9d7d-b58e72ced83a
Bressloff, Neil W
4f531e64-dbb3-41e3-a5d3-e6a5a7a77c92
Sengers, Bram G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Ahmad Bakir, Azam
09884152-5068-4dcc-9903-60ec3b088246
3 May 2025
Binti Ulta Delestri, Laila Fadhillah
6634334f-4d49-494a-a674-1874f4374d6a
Amr Al Abed,
92859790-6c3e-45a1-a6df-61ffef8ed9ec
Socrates Dokos,
5dc0e9f4-e613-4d93-8023-deaed43b2ff6
Mohamed Mokhtarudin, Mohd Jamil
71fdd149-fb8a-4d36-9bea-0a2241b801f0
Kok, Foo Ngai
9c965216-c916-493c-9d7d-b58e72ced83a
Bressloff, Neil W
4f531e64-dbb3-41e3-a5d3-e6a5a7a77c92
Sengers, Bram G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Ahmad Bakir, Azam
09884152-5068-4dcc-9903-60ec3b088246
Binti Ulta Delestri, Laila Fadhillah, Amr Al Abed, , Socrates Dokos, , Mohamed Mokhtarudin, Mohd Jamil, Kok, Foo Ngai, Bressloff, Neil W, Sengers, Bram G. and Ahmad Bakir, Azam
(2025)
Modelling of cardiac biventricular electromechanics with coronary blood flow to investigate the influence of coronary arterial motion on coronary haemodynamic.
Computer Methods and Programs in Biomedicine, 267, [108800].
(doi:10.1016/j.cmpb.2025.108800).
Abstract
Background and objective: coronary flow is strongly influenced by the geometry and motion of coronary arteries, which change periodically in response to myocardial contraction throughout the cardiac cycle. However, a computational framework integrating cardiac biventricular electromechanics with dynamic coronary artery flow using a simplified, yet comprehensive mathematical approach remains underexplored. This study aims to develop a coupled 3D model of cardiac biventricular electromechanics and coronary circulation, enabling simulation of the interplay between cardiac electrical activity, mechanical function and coronary flow.
Methods: a patient-specific biventricular electromechanical model encompasses the fibre orientation, electrophysiology, mechanical properties and an open-loop heart circulation is developed. The electromechanical model is simulated independently from the coronary circulation model. The model provides an input for the Navier-Stokes-based coronary flow model. A one-way coupling approach maps the biventricular motion to the coronary arteries, linking both components. To evaluate the influence of coronary arterial motion on coronary haemodynamic, simulations are performed for two scenarios: a moving and a non-moving (static) coronary artery model.
Results: cardiac-induced coronary motion alters the pressure, velocity and flow profiles. Non-moving coronary arteries produce stable counter-rotating Dean-like vortices due to steady flow dominated by centrifugal forces, while the moving arteries disrupt these vortices as arterial curvature changes disturb the flow. Coronary motion significantly affects the wall shear stress, highlighting the necessity of incorporating arterial dynamics to investigate atherosclerosis.
Conclusion: the integrated biventricular-coronary model emphasizes the significance of background cardiac motion in coronary haemodynamic. The model offers a foundation for exploring myocardial perfusion mechanisms in realistic physiological settings.
Text
LFUD_CleanedManuscript_Revised_3
- Accepted Manuscript
Text
1-s2.0-S0169260725002172-main
- Version of Record
Restricted to Repository staff only
Request a copy
More information
Accepted/In Press date: 20 April 2025
e-pub ahead of print date: 22 April 2025
Published date: 3 May 2025
Keywords:
Cardiac electromechanics, Cardiac motion, Cardiac-coronary coupling, Coronary blood flow, Myocardial perfusion
Identifiers
Local EPrints ID: 506162
URI: http://eprints.soton.ac.uk/id/eprint/506162
ISSN: 0169-2607
PURE UUID: 122a7ede-5e51-4c81-9134-ef0de8010bf0
Catalogue record
Date deposited: 29 Oct 2025 17:40
Last modified: 01 Nov 2025 05:01
Export record
Altmetrics
Contributors
Author:
Laila Fadhillah Binti Ulta Delestri
Author:
Amr Al Abed
Author:
Socrates Dokos
Author:
Mohd Jamil Mohamed Mokhtarudin
Author:
Azam Ahmad Bakir
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics