Structure revision of meroterpenoid natural products enabled by biomimetic total synthesis
Structure revision of meroterpenoid natural products enabled by biomimetic total synthesis
Meroterpenoids constitute a vast and structurally diverse family of natural products with mixed biosynthetic origins, found across nearly all forms of life on Earth. Despite their often intricate architectures, meroterpenoid biosynthesis follows a remarkably consistent and predictable chemical logic, driven largely by interactions between electron-rich aromatic rings and terpene-derived building blocks. However, the structural elucidation of these stereochemically complex molecules remains challenging, and misassignments are common. This review highlights the pivotal role of biomimetic total synthesis in enabling the structural reassignment of meroterpenoids, whilst also rationalising their biosynthetic origin, inspiring the design of novel cascade reactions, and even guiding the prediction and discovery of previously unknown natural products.
15333-15345
George, Jonathan H.
004df70b-45c3-479c-a9ee-48d328ef20c4
29 September 2025
George, Jonathan H.
004df70b-45c3-479c-a9ee-48d328ef20c4
George, Jonathan H.
(2025)
Structure revision of meroterpenoid natural products enabled by biomimetic total synthesis.
Chemical Communications, 61 (79), .
(doi:10.1039/d5cc04296h).
Abstract
Meroterpenoids constitute a vast and structurally diverse family of natural products with mixed biosynthetic origins, found across nearly all forms of life on Earth. Despite their often intricate architectures, meroterpenoid biosynthesis follows a remarkably consistent and predictable chemical logic, driven largely by interactions between electron-rich aromatic rings and terpene-derived building blocks. However, the structural elucidation of these stereochemically complex molecules remains challenging, and misassignments are common. This review highlights the pivotal role of biomimetic total synthesis in enabling the structural reassignment of meroterpenoids, whilst also rationalising their biosynthetic origin, inspiring the design of novel cascade reactions, and even guiding the prediction and discovery of previously unknown natural products.
Text
d5cc04296h
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Accepted/In Press date: 1 September 2025
Published date: 29 September 2025
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© 2025 The Royal Society of Chemistry.
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Local EPrints ID: 506184
URI: http://eprints.soton.ac.uk/id/eprint/506184
ISSN: 1359-7345
PURE UUID: da52c295-de4a-496f-ad89-53f493764aef
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Date deposited: 29 Oct 2025 17:45
Last modified: 29 May 2026 02:11
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Jonathan H. George
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